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Le modafinil est un mГ©dicament utilisГ© depuis les annГ©es 1970, principalement dans le traitement de la narcolepsie, et qui est actuellement Г  l'Г©tude Г  d'autres fins. C'Г©tait un dГ©veloppement conjoint entre Cephalon et Lilly, et n'a jamais Г©tГ© vendu. Le modafinil est utilisГ© hors AMM pour amГ©liorer l'attention, la concentration, la motivation et l'Г©veil. Cela peut poser des problГЁmes de pharmacocinГ©tique et l'absorption de la molГ©cule droite peut ГЄtre trГЁs variable. Cependant, le modafinil semble stimuler les zones cГ©rГ©brales impliquГ©es dans le cycle du sommeil. Modafinil Ordonnance Vous ne devez pas mГўcher ou casser un bouchon de gel dur. Les posologies doivent gГ©nГ©ralement commencer Г  un niveau bas et ГЄtre progressivement augmentГ©es sur plusieurs jours selon les besoins, jusqu'Г  la dose quotidienne de 200 mg ou la dose nocturne de 400 mg. Dans de rares cas, des Г©vГ©nements indГ©sirables graves surviennent avec le modafinil, tels que le syndrome de Stevens-Johnson et l'anaphylaxie. Le modafinil peut provoquer des maux de tГЄte, de la somnolence et des nausГ©es lorsqu'il est pris Г  fortes doses. Chez les personnes souffrant d'apnГ©e du sommeil, il peut Г©galement rГ©duire les symptГґmes de la maladie. Modafinil peut interagir avec d'autres mГ©dicaments et conditions de santГ©. Les scientifiques travaillent toujours sur la maniГЁre exacte dont ces diffГ©rents neurotransmetteurs fonctionnent ensemble. N'arrГЄtez pas de prendre du modafinil sans d'abord consulter votre mГ©decin. Il y a beaucoup de Modafinil effets secondaires, qui peuvent ГЄtre lГ©gers ou graves. Les donnГ©es pharmacologiques suggГЁrent que le modafinil a un effet sur le sous-type de la famille des rГ©cepteurs de la sГ©rotonine DA-1, qui est prГ©sent dans les zones limbiques du cerveau, le principal site d'action des stimulants dopaminergiques. Le nom В« modafinil В» vient de l'institut de recherche qui l'a dГ©veloppГ©, l'E. Aux Г‰tats-Unis, le modafinil est approuvГ© comme agent favorisant l'Г©veil pour les personnes souffrant de narcolepsie, de troubles du sommeil liГ©s au travail postГ© et d'apnГ©e du sommeil.

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Le modafinil est utilisé sous forme de spray nasal. Le modafinil est un stimulant synthétique qui affecte le SNC. Le modafinil ne semble pas avoir d'effets significatifs sur la pression artérielle, bien qu'il puisse provoquer une augmentation de la pression artérielle chez certains patients et aggraver l'hypertension chez d'autres. Le modafinil peut également être administré en une fois par jour. Il peut également interagir avec d'autres médicaments métabolisés par le foie, tels que la rifampicine, l'hydralazine, la cyclosporine, la carbamazépine et le millepertuis. Stimulant Intellectuel Sans Ordonnance L'agent actif du modafinil est l'Alprazolam, dans lequel un groupe ester est attaché au groupe benzodiazépine du médicament. Cela a conduit au lancement d'une étude en ouvert avec dix sujets qui ont reçu 400 mg par jour pendant cinq jours. Le modafinil est souvent administré sous forme de comprimé ou de suspension liquide. Le modafinil semble également affecter la sérotonine, la dopamine et l'histamine sur ses sites d'action, ce qui peut contribuer à ses effets d'amélioration cognitive. Son nom chimique est méthyl-D-amphétamine, ou éthyl N-2-méthyl-1-phénylpropylamine, et son poids moléculaire est de 233,4 grammes par mole. Les avantages du modafinil sont l'amélioration immédiate de la vigilance et des performances cognitives. Des données minimales suggèrent que les adolescents présentent une incidence plus élevée d'effets secondaires que les adultes. Lorsque le modafinil se lie aux récepteurs DA, le neurotransmetteur DA est libéré des neurones dans les espaces synaptiques entre les neurones. D'autre part, ces affirmations ne sont pas fondées sur des essais cliniques rigoureux. Il n'est pas indiqué pour le traitement de la somnolence associée à la narcolepsie. Il n'est pas approuvé pour les patients atteints de la maladie de Parkinson. Ce médicament interagit avec des médicaments contre-indiqués, ce qui signifie que leur prise en même temps que le Modafinil peut avoir des conséquences désastreuses. Le modafinil agit sur les transporteurs de la dopamine dans le noyau accumbens et est également un agoniste du récepteur de la dopamine 2. C'est un mélange racémique de deux composés, le R-Modafinil et le S-Modafinil.

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Le modafinil doit ГЄtre pris environ 30 minutes avant le coucher. La stimulation des systГЁmes noradrГ©naline et dopamine entraГ®ne Г©galement une libГ©ration d'hormones (par exemple, la prolactine, l'hormone corticotrope et l'hormone de croissance) impliquГ©es dans l'amГ©lioration de l'humeur et l'augmentation de la motivation, ainsi que dans le rythme circadien. CommercialisГ© comme traitement de la fatigue, de l'anxiГ©tГ© et du travail postГ©, le modafinil est disponible sous forme de comprimГ©s dosГ©s Г  200 mg, 300 mg et 400 mg. Le modafinil est classГ© comme substance contrГґlГ©e aux Г‰tats-Unis. La dose efficace la plus faible de Modafinil pour induire l'Г©veil sans effets secondaires est d'environ 200 mg. Le modafinil est une drogue de synthГЁse. Il en rГ©sulte une formation importante (> 70 %) et modГ©rГ©e ( Le modafinil est mГ©tabolisГ© par le CYP450 2C19 et le CYP2D6. Stimulant Intellectuel Sans Ordonnance Ceci est utilisГ© pour s'assurer que les rГ©sultats sont dus au traitement, par opposition aux effets secondaires. Modafinil interagit Г©galement avec un certain nombre de mГ©dicaments utilisГ©s dans des conditions psychiatriques. Contrairement aux amphГ©tamines, il ne garde pas l'utilisateur Г©veillГ©. Cette forme de modafinil est souvent utilisГ©e chez les personnes souffrant d'apnГ©e du sommeil, car elle permet un endormissement plus rapide et moins important tout en maintenant la vigilance. Le nom chimique du modafinil est le chlorhydrate de 1-[(diphГ©nylmГ©thyl)sulfinyl]-2-[4-(mГ©thylthio)phГ©nyl]mГ©thoxyГ©than-1-amine. Le modafinil peut ГЄtre utilisГ© Г  la place des benzodiazГ©pines, mais il est moins efficace et plus susceptible de provoquer des interactions mГ©dicamenteuses, en particulier avec l'alcool et certains mГ©dicaments anticancГ©reux, et il peut avoir une efficacitГ© moindre chez certaines personnes. Il peut ГЄtre utilisГ© par des personnes en bonne santГ© pour soulager la somnolence et par des personnes souffrant de narcolepsie ou d'apnГ©e du sommeil qui souffrent de somnolence continue. La somnolence due Г  la narcolepsie survient pendant la journГ©e, tandis que la somnolence des deux autres troubles survient la nuit. Il n'est pas approuvГ© pour cette utilisation par la FDA. Il peut ГЄtre pris par voie orale, sublinguale ou par injection.

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[Modafinil 200]

Le modafinil est disponible en doses de 200 mg, 400 mg et 600 mg. Les personnes ГўgГ©es, les femmes, les travailleurs postГ©s et les personnes souffrant de la maladie de Parkinson, de narcolepsie et d'apnГ©e du sommeil sont parmi les personnes les plus courantes qui utilisent le modafinil. Le modafinil agit Г©galement sur les rГ©cepteurs de la sГ©rotonine, mais on ne sait pas si cela augmente la neurotransmission de la sГ©rotonine. La rГ©gion du cerveau qui contrГґle la vigilance s'appelle le locus coeruleus et contrГґle le sommeil et l'Г©veil. Le modafinil bloque Г©galement la capacitГ© de l'adГ©nosine Г  rГ©duire la libГ©ration de dopamine, ce qui amГ©liore la saillance incitative de la dopamine. Comme le mГ©dicament est mГ©tabolisГ© dans le foie, il peut ГЄtre pris avec ou sans nourriture. Par consГ©quent, le modafinil force en fait le cerveau Г  devenir plus Г©veillГ© lorsqu'il est utilisГ© pendant la journГ©e. Stimulant Intellectuel Sans Ordonnance Le mГ©dicament est fabriquГ© par de nombreuses sociГ©tГ©s, dont Orion Pharma, Givlaar Pharma et Danmark Ltd. L'effet maximal est aprГЁs 10 Г  12 heures et culmine entre 12 et 24 heures. Il est dГ©conseillГ© aux personnes ayant des antГ©cГ©dents d'arythmie, d'hypertension ou de problГЁmes cardiovasculaires. Le modafinil est utilisГ© pour contrecarrer la somnolence chez les personnes atteintes de narcolepsie, une condition dans laquelle les gens Г©prouvent souvent de la somnolence mГЄme lorsqu'ils sont Г©veillГ©s, avec des crises de sommeil soudaines sans avertissement. La dose quotidienne recommandГ©e de modafinil est de 200 Г  600 mg selon l'indication. Le modafinil a un poids molГ©culaire de 712,984 et une formule structurelle de C16H16F3NO3. Il se lie au site actif du transporteur de recapture de la dopamine. Le modafinil est disponible aux Г‰tats-Unis sous le nom de marque Provigil ou sous le nom commercial Alertec. Le modafinil est une cyclopyrrolone, et ce n'est que l'un des nombreux stimulants liГ©s aux phГ©nylcyclopropylamines. Le modafinil est gГ©nГ©ralement exempt d'effets secondaires graves ; cependant, il est important que les utilisateurs connaissent les dangers potentiels des interactions avec d'autres substances.

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