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[Modafinil 200]

Le modafinil est un médicament expérimental qui a été développé pour augmenter l'éveil et améliorer les capacités cognitives. Le modafinil est structurellement similaire à l'amphétamine et à la phenmétrazine. Le modafinil, qui est une substance contrôlée aux États-Unis et dans plusieurs autres parties du monde, est disponible en vente libre aux États-Unis, ainsi que dans de nombreuses régions d'Europe et d'Asie. En 2013, Provigil a généré des revenus d'environ 1,9 milliard de dollars pour Sun Pharma. Une enzyme appelée acétylcholinestérase décompose l'acétylcholine, ce qui ralentit la circulation des messages entre les cellules nerveuses. Pour la plupart des troubles non liés au sommeil, des doses de 200 à 400 mg sont utilisées « au besoin ». Acheter Modafinil En Luxembourg Des effets psychiatriques indésirables ont été rapportés, notamment agitation, dépression, pensées suicidaires ou violentes, activité sociale et sexuelle excessive et hostilité. Le métabolisme du modafinil est le même chez tous les individus, mais diminue avec l'âge (par exemple, la demi-vie est de 3 à 5 heures chez les enfants). Modafinil est la seule forme d'Armodafinil vendue aux États-Unis. Modafinil a été commercialisé sous un certain nombre de noms de marque, notamment Provigil, Nuvigil et Armodafinil. Le médicament a d'abord été créé par la société pharmaceutique danoise Lundbeck, à l'origine comme médicament pour la narcolepsie. Le modafinil est utilisé pour réduire les symptômes de la narcolepsie, un trouble du sommeil dans lequel l'individu subit des attaques soudaines et incontrôlables de faiblesse musculaire causées par des épisodes de sommeil paradoxal (REM). Cela peut entraîner une sensation d'agitation, une sensation désagréable dans la bouche, une bouche sèche, une augmentation de la salive, un manque de transpiration, des yeux qui démangent, des picotements, une raideur de la nuque et une sensibilité accrue au bruit. Les taux sériques thérapeutiques de modafinil sont faibles. La FDA déclare que les effets secondaires du Modafinil incluent « somnolence, étourdissements, maux de tête, nausées, vomissements, douleurs abdominales, bouche sèche, agitation, tension musculaire, hallucinations, hostilité, lassitude, nervosité, anxiété, perte de libido, difficultés respiratoires, diurèse (sauf chez les patients dont la fonction rénale est altérée) et les troubles du sommeil. Le modafinil est un sous-produit de la synthèse chimique et peut coûter très cher, plus de 400 dollars américains pour un seul comprimé de 100 mg. Étant donné que le médicament est un mélange racémique de deux isomères optiques, chaque isomère a un effet pharmacologique différent.

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[Modafinil 200]

Le modafinil peut provoquer des effets secondaires tels que des nausГ©es, des Г©tourdissements et des maux de tГЄte, et il a Г©tГ© rapportГ© qu'il provoque des fringales. Cependant, une revue Cochrane de 2015 a rГ©vГ©lГ© que mГЄme si les rГ©sultats Г©taient encourageants, la qualitГ© des preuves Г©tait trГЁs faible et les conclusions doivent ГЄtre tirГ©es avec prudence. Il a Г©tГ© dГ©veloppГ© Г  l'origine par des chercheurs de l'UniversitГ© de Bordeaux. La recherche sur le modafinil est en cours, mais les rГ©sultats Г  ce jour sont mitigГ©s. Le modafinil a Г©tГ© initialement dГ©veloppГ© dans les annГ©es 1970 par le neuroscientifique Michel Jouvet et les laboratoires Lafon en tant que stimulant sГ©lectif putatif du systГЁme nerveux central. Le modafinil est un mГ©dicament d'ordonnance dГ©veloppГ© dans les annГ©es 1970 pour traiter la narcolepsie. Provigil En France Il est recommandГ© que le patient subisse une Г©valuation de base et que des Г©valuations de suivi soient programmГ©es un mois et six mois aprГЁs le dГ©but du traitement. Plus prГ©cisГ©ment, il agit en augmentant les niveaux de noradrГ©naline et de dopamine, des neurotransmetteurs. La premiГЁre base de donnГ©es de consommateurs en Europe Г  ГЄtre liГ©e Г  des informations sur la santГ© a Г©tГ© les cartes mГ©dicales irlandaises. Le modafinil ne semble pas interagir avec d'autres mГ©dicaments lorsqu'il est utilisГ© seul, mais il peut interagir avec la cafГ©ine, l'alcool, les sГ©datifs et les somnifГЁres, l'amantadine, la carbamazГ©pine, les opioГЇdes, certains antidГ©presseurs, les suppresseurs du systГЁme immunitaire, les stimulants, les statines et les antipaludГ©ens. Cela peut rГ©duire la qualitГ© du sommeil de certaines personnes. Le modafinil ne doit pas ГЄtre utilisГ© s'il existe un risque accru de crise en raison d'un trouble convulsif sous-jacent. Le modafinil est un mГ©dicament stimulant sans potentiel addictif. Le modafinil est un stimulant du systГЁme nerveux central (SNC), initialement dГ©couvert en 1972. Le modafinil semble Г©galement induire la libГ©ration d'acГ©tylcholine et de sГ©rotonine. Contrairement aux amphГ©tamines et Г  la cafГ©ine, le modafinil ne provoque pas de nervositГ©, d'insomnie ou d'irritabilitГ©. L'indication la plus courante du modafinil est le traitement de la narcolepsie (Г©galement appelГ©e hypersomnie idiopathique). Le modafinil a Г©galement Г©tГ© utilisГ© pour traiter les travailleurs postГ©s qui Г©prouvent une somnolence excessive au travail.

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La dose maximale recommandГ©e est de 400 Г  500 mg une fois par jour. Le modafinil peut ГЄtre abusГ© pour amГ©liorer la cognition. Les auteurs ont postulГ© que la raison pour laquelle cela a Г©tГ© vu est que les mГ©dicaments amГ©liorant la cognition sont destinГ©s Г  amГ©liorer les performances d'une personne sur des tГўches cognitives telles que la mГ©morisation, la prise de dГ©cision et la rГ©solution de problГЁmes. Provigil est la marque la plus frГ©quemment mentionnГ©e, tandis que Waklert est la plus connue de la gamme de mГ©dicaments Waklert. Les effets secondaires rares et graves peuvent inclure des rГ©actions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antГ©cГ©dents de psychose. Provigil En France Le modafinil se distingue des autres mГ©dicaments sur ordonnance Г  base d'amphГ©tamines en ce qu'il n'a pas de propriГ©tГ©s stimulantes. Le modafinil peut ГЄtre prescrit comme aide Г  l'endormissement et au maintien du sommeil (si nГ©cessaire) pour la narcolepsie. Il est Г©galement utilisГ© pour le traitement d'autres affections, notamment le trouble dГ©ficitaire de l'attention avec hyperactivitГ© (TDAH) et la somnolence diurne excessive chez les travailleurs postГ©s. Son effet Г©veilleur a Г©tГ© attribuГ© au blocage de l'action de l'adГ©nosine sur les rГ©cepteurs de l'adГ©nosine A1 et A2A. Il n'est pas recommandГ© chez les personnes souffrant d'arythmie, d'hypertension artГ©rielle importante ou d'hypertrophie ventriculaire gauche. La liaison aux rГ©cepteurs de la dopamine peut entraГ®ner des sentiments de rГ©compense ou de plaisir, tandis que la liaison aux rГ©cepteurs de type D1 peut entraГ®ner l'Г©veil ou l'Г©veil. C'est ainsi qu'il augmente les niveaux de ces neurotransmetteurs dans le cerveau, les rendant plus disponibles Г  l'utilisation. Le modafinil agit sur les structures cГ©rГ©brales qui rГ©gulent le cycle veille/sommeil, notamment les neurones de l'hypothalamus antГ©rieur, de l'hypothalamus dorsomГ©dian et du complexe vagal dorsal. La recherche sur le modafinil est passГ©e par deux phases. Le modafinil est un agent libГ©rant de la noradrГ©naline-dopamine Г  absorption rapide. Un certain nombre de noms de marque diffГ©rents sont disponibles, notamment Provigil, Armodafinil, Nuvigil, Ezmodafinil et Modalert. Il est classГ© par la FDA comme une substance contrГґlГ©e de l'annexe IV.

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