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Le modafinil a été autorisé par le ministère français de la Santé en 1993 et ​​a été approuvé pour la vente aux États-Unis en 1998. Utilisé seul ou en association avec un placebo, les doses ont varié de 50 à 200 mg, administrées 2 à 6 fois par jour. Il est en outre inactif en tant qu'agoniste de tout sous-type connu de récepteur de la dopamine et n'a aucun effet sur la monoamine oxydase A. Aux États-Unis, le modafinil n'est disponible que sur ordonnance. Les concentrations plasmatiques moyennes de modafinil augmentent pendant une période de 3 heures après une dose orale unique de 100 mg. Le modafinil n'est pas approuvé pour l'insomnie en soi. La FDA déclare qu'il s'agit "d'un traitement sûr et efficace pour la somnolence du travail posté", sans aucune étude de sécurité à long terme approuvée. Modafinil Maroc Prix Les stimulants du SNC augmentent l'éveil, l'attention et/ou l'irritabilité et sont utilisés pour traiter la somnolence due à la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. Le modafinil s'est avéré aussi efficace que l'armodafinil, un médicament sur ordonnance, pour le traitement de la somnolence excessive et de la fatigue chez les personnes atteintes de narcolepsie. Le modafinil a été développé dans les années 1970 par le neuroscientifique français Michel Jouvet et les laboratoires Lafon. Les enfants sont plus sensibles aux effets secondaires. Une gélule de 120 mg fournit 100 mg de modafinil. Aux États-Unis, il est vendu sous les noms de Narcolept, Provigil, Provigil 20 mg et Vyvanse, entre autres noms de marque. Certains suggèrent que le modafinil soit utilisé comme complément alimentaire pour l'amélioration cognitive. Le modafinil, comme les autres stimulants du SNC, peut provoquer des étourdissements ou de la somnolence lors de la conduite ou de l'utilisation de machines, en particulier s'il est pris après l'alcool. Le modafinil peut être pris à 200, 300, 400 ou 600 mg. Le modafinil est généralement bien toléré. La dose recommandée de Modafinil est de 300 mg, à prendre 1 à 4 heures avant le coucher. La noradrénaline est un neurotransmetteur qui régule l'éveil et l'éveil. Le modafinil est une substance active extraite de cultures industrielles et agricoles.

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Le modafinil serait mГ©tabolisГ© par l'isoenzyme 3A4 du cytochrome hГ©patique P450 (CYP). Le modafinil soulage Г©galement les symptГґmes des troubles du sommeil tels que les troubles du sommeil liГ©s au travail postГ© et l'apnГ©e obstructive du sommeil, en aidant Г  augmenter la vigilance tout au long de la journГ©e. C'est un dГ©rivГ© d'amines cycliques aliphatiques et un puissant activateur dopaminergique. Il peut Г©galement ГЄtre pris sous forme de gel, d'injectable ou d'inhalateur. Le mГ©canisme d'action du modafinil n'est cependant pas complГЁtement compris et des questions ont Г©tГ© soulevГ©es quant au mГ©canisme de ses effets. Provigil En France Dans une Г©tude en ouvert, les doses variaient de 100 mg/jour Г  500 mg/jour. Le modafinil est utilisГ© hors AMM comme prГ©tendu activateur cognitif pour amГ©liorer l'Г©veil. Le modafinil est Г©galement Г  l'Г©tude pour le traitement du trouble dГ©ficitaire de l'attention avec hyperactivitГ© (TDAH). Le modafinil semble sans danger chez les enfants et les adultes. Le modafinil peut ГЄtre utilisГ© pour traiter la narcolepsie et les troubles du sommeil liГ©s au travail postГ©. Il a Г©tГ© dГ©montrГ© que le mГ©tabolite est environ 50 Г  100 fois moins puissant que le modafinil actif. Sa formule molГ©culaire est C14H17ClN3O2S. La proportion de patients affectГ©s par le modafinil par rapport au placebo Г©tait importante dans tous les essais (intervalle de taille d'effet = -0,78 Г  -1,2, selon le critГЁre d'Г©valuation), et la durГ©e des essais Г©tait d'une semaine ou plus. Le modafinil n'est pas un dispositif mГ©dical ni un mГ©dicament vГ©tГ©rinaire. L'activitГ© pharmacologique principale du modafinil est celle d'un puissant antagoniste des rГ©cepteurs H1 de l'histamine. En plus d'avoir une demi-vie relativement courte, le modafinil n'agit pas autant sur les systГЁmes noradrГ©nergiques ou sГ©rotoninergiques centraux que l'amphГ©tamine. Aux Г‰tats-Unis, les noms de marque du mГ©dicament incluent Provigil, Armodafinil et Nuvigil. Le modafinil ne doit pas ГЄtre confondu avec le modafinil-aluminium ou le modafinil-L, qui sont deux formes inertes du mГ©dicament. Il est souvent utilisГ© pour rГ©duire la somnolence diurne chez les personnes souffrant d'apnГ©e obstructive du sommeil.

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Il est Г©galement utilisГ© pour traiter les troubles du sommeil liГ©s au travail postГ© (SWSD), un groupe de troubles qui surviennent pendant un quart de travail et obligent les personnes Г  travailler en dehors de leurs heures habituelles. Le traitement par modafinil a une demi-vie de 10,7 heures. Le modafinil est disponible sous trois formes : citrate, citrate et citrate citrate. Le modafinil est classГ© comme un "nootrope" qui est utilisГ© pour "amГ©liorer largement les performances cognitives". On suppose qu'il a des propriГ©tГ©s nootropiques ou favorisant l'Г©veil, probablement en stimulant le cortex prГ©frontal ventromГ©dian et les zones associГ©es du cerveau. Provigil En France Chez les personnes souffrant d'apnГ©e du sommeil, il peut y avoir des Г©pisodes de niveaux d'oxygГЁne dans le sang (comme dans le cerveau et le cЕ“ur) qui chutent en dessous des niveaux normaux pendant le sommeil. Les effets secondaires du modafinil comprennent des maux de tГЄte, des troubles du sommeil, des nausГ©es et des problГЁmes de foie. Modafinil n'est pas l'orthographe correcte de ce nom. Le modafinil aide Г  prГ©venir la somnolence pendant l'Г©veil et aidera le patient Г  obtenir plus de clartГ© et de concentration lors de l'utilisation du mГ©dicament. Les scientifiques ne sont toujours pas certains des mГ©canismes d'action prГ©cis, cependant, on pense que le modafinil peut augmenter la quantitГ© d'acГ©tylcholine dans le cerveau. Le modafinil peut Г©galement ГЄtre utilisГ© pour traiter les troubles du sommeil liГ©s au travail postГ©, oГ№ une personne dort Г  son heure normale, mais maintient sa vigilance pour Г©viter de s'endormir sur son lieu de travail. Une stimulation diurne a Г©tГ© rapportГ©e avec le traitement par le modafinil. Dans un cadre de recherche contrГґlГ©, il a Г©tГ© rapportГ© que les personnes qui consommaient une forte dose de drogue ressentaient moins de somnolence, obtenaient de meilleurs rГ©sultats sur les tГўches de mГ©moire et de concentration, et avaient une vigilance accrue et une concentration amГ©liorГ©e jusqu'Г  huit heures. Il n'est pas approuvГ© pour d'autres troubles tels que le travail postГ©, l'apnГ©e obstructive du sommeil ou pour une utilisation comme stimulant cognitif chez les adultes en bonne santГ©. Il est gГ©nГ©ralement pris 1 Г  2 heures avant le coucher, bien que les effets puissent prendre jusqu'Г  6 heures pour se dГ©velopper.

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