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Le modafinil peut Г©galement ГЄtre efficace pour le traitement de la narcolepsie. Le modafinil s'avГЁre utile pour amГ©liorer l'Г©tat d'Г©veil et la qualitГ© de la vigilance des patients atteints de narcolepsie et de troubles du travail postГ©. Le mГ©canisme d'action du modafinil a Г©tГ© Г©tudiГ© en dГ©tail mais n'est pas entiГЁrement compris. Il en rГ©sulte une augmentation de la concentration extracellulaire de ces catГ©cholamines, dont il a Г©tГ© dГ©montrГ© qu'elle augmente l'Г©veil et amГ©liore les performances cognitives. Les personnes atteintes de glaucome, de troubles psychiatriques comme la dГ©pression, la manie ou la psychose, et d'autres troubles mГ©dicaux comme l'anГ©mie, l'asthme ou les troubles cardiovasculaires doivent Г©viter ou utiliser avec prudence. En plus d'amГ©liorer l'activitГ© et le comportement diurnes, le modafinil peut Г©galement soulager les symptГґmes de somnolence. La biodisponibilitГ© absolue moyenne de la formulation orale est de 47 %. Modafinil Ordonnance Le modafinil est un inhibiteur sГ©lectif, rГ©versible et de haute affinitГ© de la recapture dopaminergique. Les mГ©dicaments contenant du modafinil peuvent ne pas ГЄtre sГ»rs chez les personnes souffrant de problГЁmes cardiaques, d'Г©pilepsie ou d'une maladie du foie. Cependant, il existe peu de preuves de cela Г  des doses infГ©rieures Г  200 mg par jour. Le modafinil peut Г©galement avoir Г©tГ© commercialisГ© comme stimulant pour amГ©liorer la concentration chez les Г©tudiants et les professeurs d'universitГ©. En amГ©liorant la concentration, vous pouvez acquГ©rir une meilleure concentration, mГЄme si cela ne conduit pas Г  un Г©tat de vigilance de longue durГ©e. Pour dГ©velopper une tolГ©rance au modafinil, vous pouvez augmenter la dose Г  100 mg, 150 mg ou 200 mg par jour. Il le fait en augmentant le taux de libГ©ration de ces hormones, et ses effets durent plus longtemps et sont plus intenses que ceux de la cafГ©ine. Aux Г‰tats-Unis, le modafinil est disponible en tant que mГ©dicament gГ©nГ©rique pour le traitement de la somnolence associГ©e Г  la narcolepsie ou Г  d'autres troubles. Le modafinil est distinct de la famille et agit sГ©lectivement comme un stimulant du systГЁme nerveux central, augmentant l'Г©veil. Les pilules de 200 mg ont des effets lГ©gГЁrement plus forts que les pilules de 100 mg. Le GABA est un neurotransmetteur majeur dans le cerveau et il est connu pour jouer un rГґle dans la rГ©gulation de la vigilance, des Г©motions, de la mГ©moire et du sommeil. Il est prescrit en une dose deux fois par jour, qui pour une dose importante serait jusqu'Г  400 milligrammes par comprimГ©, mais peut ГЄtre infГ©rieure en fonction des besoins cliniques.

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Le modafinil est un stimulant à action centrale. Il affecte les neurotransmetteurs noradrénaline et dopamine en bloquant leurs pompes de recapture, augmentant leurs niveaux dans la synapse (espace entre les neurones). Un test utilisé pour évaluer la capacité métabolique d'un individu pour la clairance hépatique de la drogue utilise l'isoenzyme acétyl-para-aminophénol, qui se trouve sous forme conjuguée en tant que constituant du métabolite hydroxy-modafinil. Le modafinil, un dérivé chimique d'une herbe appelée antabuse, est un stimulant du système nerveux central utilisé pour traiter la fatigue et les problèmes de sommeil. Le modafinil est un médicament stimulant délivré sur ordonnance et a été étudié pour un certain nombre d'utilisations, notamment le traitement de la narcolepsie, des troubles du sommeil liés au travail posté et de l'apnée obstructive du sommeil, ainsi que comme un éventuel activateur cognitif pour améliorer l'éveil. Le modafinil se prend par voie orale, se présente sous forme de comprimés de 100 mg et 200 mg et est commercialisé sous des formes à usage récréatif. Modafinil Ordonnance Il est également approuvé par la FDA pour certaines conditions médicales, notamment le traitement de la somnolence excessive associée à la narcolepsie chez les enfants. Il s'agit d'un stimulant du système nerveux qui a été utilisé hors AMM comme prétendu activateur cognitif pour améliorer l'éveil dans des études animales et humaines, mais les preuves de son efficacité en tant qu'activateur cognitif restent anecdotiques. Les sociétés pharmaceutiques Adamed et Shionogi et la société agricole Romik ont ​​développé le modafinil avec l'approbation de la Food and Drug Administration (FDA) des États-Unis. Il a été développé en France par Michel Jouvet et les Laboratoires Lafon. Provigil est un stimulant du système nerveux central dont on pense qu'il exerce ses effets en augmentant l'éveil. L'activité accrue des cellules cérébrales libère de la sérotonine. Le modafinil fait également disparaître ses effets plus rapidement que certains autres médicaments disponibles sur le marché. Il est structurellement similaire au psychostimulant américain méthylphénidate et aux agents dopaminergiques méthamphétamine, apomorphine et lévodopa. S'il n'est pas pris le matin, il a tendance à perdre de son efficacité. Les patients prenant des médicaments qui stimulent le cytochrome P450 CYP3A4 (par exemple, la rifampicine, la rifabutine) peuvent présenter une augmentation des effets secondaires tels que des maux de tête, une dyspepsie ou des nausées. Le modafinil doit être conservé à température ambiante dans un endroit sec. Le modafinil doit être utilisé à des doses plus faibles au départ, et peut être progressivement augmenté. Le modafinil offre un mode d'action différent des psychostimulants traditionnels tels que l'amphétamine ou le sulfate de dextroamphétamine. C'est un agent pro-cognitif, augmentant la capacité à résoudre les problèmes, à bien réussir les examens et à se concentrer.

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