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Le modafinil est rapidement absorbé après administration orale et subit un important métabolisme de premier passage dans le foie, et est largement métabolisé en trois métabolites actifs : le N-desméthylmodafinil, le N-déséthylimidafinil et le N-desméthylarmodafinil. Son nom chimique est 2-(diphénylméthyl)benzimidazole. La dose quotidienne normale de modafinil est de 200 à 600 mg pris par voie orale 3 à 4 fois par jour. Il est commercialisé comme traitement des troubles du sommeil liés au travail posté et de la somnolence excessive. Modafinil dans les études animales a été montré pour augmenter l'éveil, peut-être en améliorant la transmission de la dopamine dans le cerveau. Il existe plusieurs façons possibles d'agir sur le modafinil pour augmenter l'éveil et la vigilance. Le modafinil est un stimulant du système nerveux central (SNC) qui agit sur les récepteurs de la dopamine dans le cerveau et est approuvé comme traitement de la somnolence excessive associée à la narcolepsie ou aux troubles du sommeil liés au travail posté. On ne sait pas comment fonctionne le modafinil ou comment il interagit avec le corps humain. Dans la narcolepsie, il réduit la cataplexie. Il est utilisé pour traiter les symptômes d'une hygiène de sommeil inadéquate dans l'environnement domestique, en particulier la difficulté à s'endormir, le réveil tôt le matin et la sensation de fatigue au réveil. Le médicament est présenté dans The Matrix et le jeu vidéo Rock Band. Tous sont formulés dans la même base inactive. Le modafinil est chimiquement connu sous le nom de 1-[(diphényl)méthyl]-1-[(diphényl)méthoxy]butan-2-ol. Modafinil-SR et Modafinil-LA sont la même substance avec la seule différence étant la présence de différents sels. Lorsque le modafinil est absorbé dans la circulation sanguine, il se fixe aux récepteurs de l'adénosine A1 et de la dopamine D4 (les récepteurs D2 sont responsables des effets secondaires de ce médicament), entraînant une augmentation de la dopamine et de la noradrénaline dans le striatum. Nootropique En France Les effets du modafinil durent jusqu'à huit heures après la prise d'une dose. Le modafinil ne semble pas interagir avec le tabagisme, bien que d'autres études cliniques soient nécessaires pour confirmer son innocuité chez les fumeurs. Il n'y a pas de limite de temps spécifique pour prendre les comprimés, mais les intervalles habituels recommandés entre les doses sont de 6 à 9 heures. On pense que le modafinil augmente les niveaux d'adrénaline dans le corps, ce qui pourrait expliquer pourquoi il est capable d'améliorer les performances cognitives chez les personnes ayant de faibles niveaux de ce neurotransmetteur. Ces neurotransmetteurs agissent sur les récepteurs adrénergiques, dopaminergiques et sérotoninergiques. Il est également utilisé pour traiter la cataplexie, une somnolence excessive survenant en conjonction avec une crise d'hallucinations hypnagogiques ou hypnopompiques. Le modafinil active le transporteur de la dopamine dans des régions spécifiques du cerveau, y compris les lobes frontaux et le cortex. Certains patients ont des doses augmentées ou diminuées si le niveau de vigilance n'est pas satisfaisant, et la dose peut être ajustée en fonction des symptômes. Bien qu'aucune étude de grande envergure n'ait été réalisée sur l'efficacité du modafinil pour la perte de poids ou à d'autres fins thérapeutiques, un examen des preuves en 2012 a indiqué que l'explication la plus probable des effets antidépresseurs et anti-anxiété du modafinil est la régulation des neurotransmetteurs et des circuits neuronaux correspondants. La dose la plus efficace dépend de la personne traitée et peut varier en fonction de la cause sous-jacente de la somnolence, de l'âge, du sexe, du poids corporel et d'autres facteurs. Le modafinil agit en augmentant les niveaux des neurotransmetteurs dopamine et noradrénaline dans le cerveau et en réduisant la somnolence, la fatigue et la somnolence causées par la diminution des niveaux des neurotransmetteurs. Le modafinil est également approuvé pour le traitement de la somnolence diurne excessive associée au syndrome d'hypoventilation centrale congénitale (CCHS) chez les patients pédiatriques. C'est un stimulant du système nerveux central, disponible pour une utilisation dans la prévention de la somnolence diurne excessive associée à un certain nombre de troubles du sommeil. La posologie recommandée de modafinil est de 100 à 200 mg par jour (un à deux comprimés de 100 mg le matin et un à deux comprimés de 100 mg le soir).

Nootropique En Pharmacie Provigil En Belgique Acheter Modafinil Sans Ordonnance Modvigil En Ligne Modafinil Europe 41e1f7b
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