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C'est un stimulant du systГЁme nerveux central, disponible pour une utilisation dans la prГ©vention de la somnolence diurne excessive associГ©e Г  un certain nombre de troubles du sommeil. La formulation typique de modafinil contient 200 mg ou 400 mg. Le modafinil semble agir Г  son maximum dans les systГЁmes dopaminergiques mГ©solimbique et nГ©ocortical, fournissant l'Г©veil plutГґt que l'amГ©lioration de l'Г©veil existant. Le modafinil est une poudre cristalline blanche Г  blanc cassГ©, inodore, non hygroscopique et lГ©gГЁrement soluble dans l'eau. En 2004, un brevet a expirГ© sur Modafinil, et l'ingrГ©dient principal est devenu plus largement disponible en version gГ©nГ©rique. Il est disponible en quatre dosages : 200 mg, 400 mg, 600 mg et 800 mg. Il peut Г©galement ГЄtre utilisГ© pour le dГ©calage horaire et pour augmenter l'Г©veil des personnes souffrant de lГ©sions cГ©rГ©brales traumatiques. Cependant, les recherches sont insuffisantes pour dГ©terminer si les avantages du mГ©dicament l'emportent sur les risques et les coГ»ts. Il diminue la somnolence et la somnolence diurne excessive en augmentant l'Г©veil. Il peut exacerber les effets de l'amphГ©tamine et rГ©duire l'efficacitГ© des mГ©canismes de rГ©gulation naturels de l'organisme. On pense que l'antagonisme des rГ©cepteurs de l'adГ©nosine A1 est l'un des mГ©canismes par lesquels le modafinil provoque une augmentation de l'Г©veil. Cela peut rГ©sulter d'une narcolepsie, d'un trouble du sommeil liГ© au travail postГ© ou d'une complication d'une condition mГ©dicale sous-jacente telle qu'une apnГ©e du sommeil. Provigil Achat Il fonctionne en augmentant l'activitГ© de la dopamine dans le cerveau. Le modafinil imite les effets de la cafГ©ine, mais a un effet plus doux que la cafГ©ine. Il a Г©galement Г©tГ© utilisГ© pour le traitement du syndrome des jambes sans repos (SJSR), du retard mental et pour traiter la somnolence de certaines personnes souffrant d'apnГ©e obstructive du sommeil. L'acГ©tylcholine est un neurotransmetteur qui provoque l'activation des neurones. Le sevrage Г©tait plus susceptible de se produire chez les personnes ayant un faible niveau de somnolence de base, mais les participants ont dГ©clarГ© que le mГ©dicament les avait rГ©veillГ©s. Modafinil a quelques effets secondaires. Le modafinil est une substance synthГ©tique, non dГ©rivГ©e d'une source naturelle. L'agent actif du modafinil est l'Alprazolam, dans lequel un groupe ester est attachГ© au groupe benzodiazГ©pine du mГ©dicament. Il a une demi-vie d'environ 12 heures et se lie trГЁs peu aux rГ©cepteurs cholinergiques. C'est-Г -dire qu'un faible taux de mГ©tabolisme et un taux d'absorption lent peuvent ГЄtre associГ©s Г  un effet de premier passage.

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somnolence du grand public. Le mГ©tabolisme in vitro avec le CYP3A4 recombinant a montrГ© qu'au niveau thГ©rapeutique, seulement 10 % du mГ©dicament parent est mГ©tabolisГ©. Des Г©tudes montrent que l'utilisation prolongГ©e du modafinil pourrait entraГ®ner une perte du rythme circadien normal. Vous ne devez pas mГўcher ou casser un bouchon de gel dur. Il peut causer des maux de tГЄte s'il est pris avec des boissons contenant de la cafГ©ine ou de l'alcool. Le modafinil n'est pas approuvГ© pour ГЄtre utilisГ© pour amГ©liorer la vigilance pour les tГўches quotidiennes telles que la conduite. Le modafinil peut provoquer des effets secondaires, les effets secondaires les plus frГ©quemment signalГ©s Г©tant notamment des troubles du sommeil, des nausГ©es, des Г©tourdissements, des maux de tГЄte et une frГ©quence cardiaque anormale. Le modafinil est classГ© comme un composГ© sympathomimГ©tique de type amphГ©tamine, ce qui signifie qu'il augmente la vigilance mentale, la concentration et l'activitГ© comportementale, tout en diminuant la somnolence. Cela peut Г©galement amГ©liorer l'humeur. On ne sait pas si le modafinil est plus puissant que l'amphГ©tamine, ou tout autre effet de la nature de la phГ©nГ©thylamine. Le modafinil est commercialisГ© depuis le milieu des annГ©es 1980, initialement en France sous le nom de Provigil. Il est parfois utilisГ© pour rester Г©veillГ© dans des situations oГ№ le sommeil de routine serait considГ©rГ© comme dangereux, comme conduire une voiture ou faire fonctionner une machinerie lourde. Bien qu'il ne s'agisse pas d'un mГ©dicament de l'annexe II ou III, le modafinil est approuvГ© pour un usage mГ©dical uniquement, car il n'est pas approuvГ© pour un usage rГ©crГ©atif ou disponible sur Internet. On pense que des niveaux Г©levГ©s de dopamine sont associГ©s Г  des troubles du mouvement tels que la maladie de Parkinson. Le modafinil est utilisГ© pour traiter la narcolepsie, les troubles du sommeil liГ©s au travail postГ© et l'apnГ©e obstructive du sommeil. Provigil Achat Avec une dose typique, les personnes ont dГ©clarГ© se sentir В« plus Г©veillГ©es В» et ГЄtre capables de В« rester conscientes et conscientes В» mГЄme lorsqu'elles somnolent. Il est disponible sous forme de comprimГ©s de 50 ou 100 mg. Le modafinil est un stimulant qui affecte le systГЁme nerveux central. Le modafinil n'est pas destinГ© aux personnes allergiques ou sensibles Г  tout mГ©dicament et est disponible en une seule dose de 100 milligrammes. ГЂ fortes doses, il peut favoriser l'Г©veil chez les personnes en bonne santГ©, en particulier celles qui doivent rester Г©veillГ©es pendant de longues pГ©riodes. Le modafinil sublingual est une poudre cristalline blanche Г  blanc cassГ©. Le mГ©dicament modafinil est disponible sous diffГ©rentes formes et doses pour faciliter l'utilisation. La forme liquide en vente libre (OTC) n'a pas d'emballage. La formule molГ©culaire est C14H14N2O et le poids molГ©culaire est de 222,27 g/mole. La recherche a montrГ© que la prise de modafinil avant un grand Г©vГ©nement peut amГ©liorer les performances intellectuelles. Des doses de modafinil relativement faibles peuvent ne pas produire la mГЄme quantitГ© d'Г©veil ou prГ©venir la somnolence qui est gГ©nГ©ralement causГ©e par la privation de sommeil. Son effet activateur de rГ©veil est puissant et il n'a qu'un effet stimulant modГ©rГ©.

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Le modafinil est pris par voie orale et la posologie est basée sur le poids corporel. Le modafinil ne doit pas être utilisé chez les personnes ayant des antécédents d'arythmie (fréquence ou rythme cardiaque irrégulier), d'hypertrophie ventriculaire droite (artère pulmonaire envahissante entraînant une hypertrophie ventriculaire droite) ou d'antécédents de psychose. Il a été approuvé aux États-Unis en 1998 pour le traitement de la somnolence excessive associée à la narcolepsie et à l'hypersomnie idiopathique et depuis lors, il a été utilisé hors AMM par les consommateurs et les professionnels de la santé pour une variété d'autres troubles, notamment les troubles du sommeil liés au travail posté et les troubles obstructifs. Il contient 200 mg de modafinil et est indiqué pour le traitement de la somnolence excessive associée à la narcolepsie, des troubles du sommeil liés au travail posté et de l'apnée obstructive du sommeil. Il peut agir comme un facilitateur de la production naturelle de dopamine par l'esprit en redirigeant le flux neuronal de dopamine qui se produit lorsque la personne est éveillée. Le médicament a d'abord été commercialisé publiquement aux États-Unis par Alza Corporation sous le nom de Provigil et Cova Pharmaceuticals sous le nom de Nuvigil. Le modafinil peut être appelé «agents favorisant l'éveil», «agents stimulants pour l'éveil», «agents adrénergiques» et «agents élévateurs». De rares réactions dermatologiques graves peuvent survenir chez les personnes présentant des prédispositions génétiques et plus fréquemment chez les patients pédiatriques. Lorsqu'il est combiné avec un ou plusieurs autres stimulants du SNC tels que l'amphétamine, le modafinil ne doit pas être pris plus de trois fois par jour. L'effet du modafinil dure entre 4 et 6 heures, et bien qu'il soit clairement perceptible, il est par ailleurs similaire à être éveillé. C'est le résultat du rephasage des oscillations lentes de l'EEG du cerveau. Certaines personnes utilisent deux pilules à la fois (une le matin et une le soir avant de se coucher), et d'autres divisent la dose deux fois le matin. Le modafinil est un médicament sur ordonnance disponible aux États-Unis en tant que médicament en vente libre et en tant que médicament générique. Il traverse la barrière hémato-encéphalique et interagit avec les récepteurs de l'hypothalamus et du tronc cérébral. Provigil Achat Le modafinil est disponible sous forme de comprimés oraux de 10 à 200 mg, avec une seule marque disponible aux États-Unis. Le modafinil est actif chez les deux sexes, mais n'a pas montré de différences d'efficacité entre les sexes. C'est un métabolite actif du stimulant méthylphénidate, qui est un agoniste indirect de la dopamine. Le modafinil est un exemple de médicament stimulant. Bien qu'il soit approuvé par la Food and Drug Administration (FDA) comme sûr et efficace pour le traitement de la somnolence diurne excessive associée à la narcolepsie et à l'hypersomnie idiopathique, il a des indications limitées. Le modafinil est un composé hétérocyclique aromatique. Le nom commercial Modafinil est une marque déposée de la société pharmaceutique française, le pharma, dont le siège est à Lille, en France. Le modafinil stimule les neurones du locus coeruleus. Les effets secondaires possibles comprennent des maux de tête, des troubles du sommeil et des nausées. Le modafinil est vendu sous le nom commercial de Provigil et on prétend qu'il augmente la vigilance mentale.

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