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Le principal ingrГ©dient actif est le chlorhydrate de modafinil, disponible sous le nom de mГ©dicament gГ©nГ©rique modafinil. La durГ©e habituelle du traitement est de 3 Г  6 mois et peut ГЄtre plus longue si nГ©cessaire. Le mГ©canisme d'action spГ©cifique est inconnu, mais le modafinil peut agir sur les zones du cerveau impliquГ©es dans le sommeil. Il a Г©tГ© dГ©montrГ© que dans les deux heures suivant la prise de Modafinil, le corps produira naturellement plus d'hormones du sommeil. La majoritГ© des recherches Г©valuant le modafinil a Г©tГ© rГ©alisГ©e chez des enfants et des adolescents atteints de TDAH. Modafinil a plusieurs noms lГ©gГЁrement diffГ©rents qui montrent son origine en France. deux heures avant le coucher. Modiodal Drogue Le modafinil augmente les niveaux d'acГ©tylcholine d'environ 60 %. Il peut agir en agissant plus ou moins directement sur les rГ©cepteurs de la dopamine et/ou en inhibant la pompe de recapture de la dopamine. Le modafinil est gГ©nГ©ralement pris environ 1 heure avant le coucher. Il en rГ©sulte une rГ©ponse favorisant l'Г©veil qui dure jusqu'Г  24 heures, alors que les effets typiques des amphГ©tamines ne sont observГ©s que pendant des heures. Le modafinil augmente le flux sanguin et on pense Г©galement qu'il traverse la barriГЁre hГ©mato-encГ©phalique. Les effets indГ©sirables ne diffГЁrent pas significativement de ceux des autres drogues de type amphГ©tamine, bien qu'ils puissent ГЄtre plus perceptibles lors de la prise d'une dose Г©levГ©e. Depuis 2015, il est disponible uniquement sur ordonnance, avec un prix de gros de 185 $ US pour 100 comprimГ©s. Le modafinil doit ГЄtre pris avec de la nourriture. Le groupe a Г©tГ© divisГ© en deux, certains prenant du modafinil et d'autres un placebo. Contrairement aux amphГ©tamines et Г  la cafГ©ine, le modafinil ne provoque pas de nervositГ©, d'insomnie ou d'irritabilitГ©. п»їLe modafinil a Г©tГ© dГ©veloppГ© dans les annГ©es 1970 par les laboratoires Michel Jouvet et Lafon et a Г©tГ© approuvГ© pour un usage mГ©dical aux Г‰tats-Unis en 1998. Il est utilisГ© sous forme de comprimГ©, pris par voie orale.

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