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Plusieurs doses peuvent ГЄtre prises en mГЄme temps le matin. Il est rapidement absorbГ© aprГЁs administration orale et rapidement distribuГ© dans la plupart des tissus et fluides. Ses effets sont principalement observГ©s Г l'Г©tat de veille. Le modafinil n'interagit pas avec d'autres mГ©dicaments et n'est pas connu pour avoir des effets de sevrage physiques ou psychologiques. Le modafinil est un activateur de dopamine. Modiodal Drogue Cela pourrait expliquer pourquoi l'action favorisant l'Г©veil du modafinil semble ГЄtre supГ©rieure Г son effet d'alerte. La dose quotidienne maximale est de 400 mg. Modafinil diffГЁre structurellement en ayant un groupe phГ©nyle supplГ©mentaire attachГ© Г l'azote Г l'extrГ©mitГ© de la molГ©cule. Certains suggГЁrent que le modafinil soit utilisГ© comme complГ©ment alimentaire pour l'amГ©lioration cognitive. Le modafinil, ou 2-[(diphГ©nylmГ©thyl)sulfinyl]-acГ©tamide, est un agent favorisant l'Г©veil Г action rapide et courte. Ses effets sont similaires Г ceux de l'amphГ©tamine, le modafinil fournissant les effets favorisant l'Г©veil de la substance, sans les effets rГ©parateurs de l'amphГ©tamine. Il ne semble pas altГ©rer la sensibilitГ© des rГ©cepteurs ou provoquer une dГ©sensibilisation des rГ©cepteurs. Il a peu ou pas d'effet sГ©datif. Ceux-ci comprennent la congestion nasale, la vision floue, l'irritation des sinus, les problГЁmes sexuels, les maux de tГЄte, les maux de dos, les Г©tourdissements et la rougeur des yeux. On pense Г©galement qu'il amГ©liore la cognition, la vigilance et la concentration chez les personnes sans troubles du sommeil. Il est Г©galement utilisГ© hors AMM en psychiatrie, en thГ©rapie cognitivo-comportementale (TCC) et comme aide pour traiter les troubles du sommeil liГ©s au travail postГ©. D'autres interactions mГ©dicamenteuses doivent ГЄtre notГ©es, en particulier avec des mГ©dicaments qui inhibent la capacitГ© de l'organisme Г mГ©taboliser certains mГ©dicaments. Il est Г©galement approuvГ© pour une utilisation chez les adultes pour traiter la somnolence excessive causГ©e par le travail postГ©. Le modafinil est un agoniste indirect de la dopamine, qui se lie aux transporteurs de la dopamine.
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Le modafinil améliore les habitudes de sommeil, ce qui entraîne un cycle de sommeil plus profond et réparateur. Il est utilisé hors AMM aux États-Unis pour augmenter l'éveil chez certains individus. Le modafinil se prend par voie orale, souvent avec une boisson énergisante ou du café. Les effets secondaires du modafinil ne sont pas bien connus. Le modafinil est vendu sous le nom commercial de Provigil et on prétend qu'il augmente la vigilance mentale. Modiodal Drogue Le modafinil peut interagir avec les antidépresseurs et doit être utilisé avec prudence ou complètement évité chez les personnes ayant des antécédents de dépression. Certaines études rapportent une mise en garde sur un risque potentiel d'addiction en cas d'utilisation prolongée. Les enfants dans cette gamme de doses ne devraient pas prendre de poids significatif. Le modafinil ne doit pas être utilisé par les personnes prenant certains médicaments tels que ceux qui modifient la façon dont le corps régule la sérotonine ou la noradrénaline, y compris plusieurs antidépresseurs. Certaines études ont montré qu'une certaine quantité d'exposition à la lumière de faible intensité peut être utilisée comme stratégie non pharmacologique pour aider à réduire la somnolence, en particulier dans le travail posté et le décalage horaire, où la luminothérapie à haute intensité s'est avérée efficace. Étant donné que les effets de la caféine et du modafinil se produisent simultanément, les utilisateurs de ces médicaments les décrivent souvent comme ayant un effet "similaire". Le modafinil est un stimulant du SNC, ou un activateur cognitif, utilisé pour traiter la somnolence excessive (narcolepsie) associée au trouble du sommeil humain, trouble du cycle veille-sommeil. Il a été développé à l'origine par des chercheurs de l'Université de Bordeaux. Le modafinil est un médicament lipophile qui passe facilement dans la barrière hémato-encéphalique. Le modafinil contient une molécule inerte (ne provoque pas de réponse dans le corps) appelée homosapien. Il est pris par la bouche. Le modafinil peut être utilisé en combinaison avec d'autres produits pour renforcer les effets. D'autres médicaments peuvent inhiber les effets du modafinil et amplifier leurs effets. Les effets secondaires rares et graves peuvent inclure des réactions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antécédents de psychose. Produit pharmaceutique à courte durée d'action, il améliore l'éveil en agissant sur le récepteur des benzodiazépines pour renforcer les effets favorisant l'éveil du neurotransmetteur GABA.
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