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La quantitГ© de modafinil nГ©cessaire pour amГ©liorer la concentration et l'attention est gГ©nГ©ralement faible. Lorsque le modafinil est absorbГ© dans la circulation sanguine, il se fixe aux rГ©cepteurs de l'adГ©nosine A1 et de la dopamine D4 (les rГ©cepteurs D2 sont responsables des effets secondaires de ce mГ©dicament), entraГ®nant une augmentation de la dopamine et de la noradrГ©naline dans le striatum. Le modafinil est disponible sous le nom de mГ©dicament de marque ProvigilВ® et sous forme de mГ©dicament gГ©nГ©rique. Il peut ГЄtre utile comme traitement des troubles du sommeil chez les personnes atteintes de trouble bipolaire ou de schizophrГ©nie, mais des recherches supplГ©mentaires sont nГ©cessaires Г ce sujet. Le modafinil appartient Г une classe de mГ©dicaments appelГ©s stimulants du SNC, utilisГ©s pour traiter la somnolence. Cependant, le modafinil est approuvГ© comme mГ©dicament d'ordonnance pour le traitement de l'insomnie, de la somnolence diurne excessive liГ©e Г l'apnГ©e du sommeil, de la narcolepsie et des troubles du sommeil liГ©s au travail postГ©. Nootropique En Pharmacie La structure du modafinil est similaire Г celle de l'amphГ©tamine stimulante, mais elle ne se lie pas Г un transporteur de dopamine. Le d et le l-thrГ©o-modafinil prГ©sentent une activitГ© pharmacodynamique dans les Г©tudes in vitro. Les mГ©dicaments suppresseurs dГ©jГ pris fonctionnent bien avec le modafinil, de sorte que les personnes atteintes de maladies comme le TDAH constateront que l'utilisation du modafinil en combinaison avec leurs mГ©dicaments leur permettra de contrГґler plus prГ©cisГ©ment leur cycle de sommeil. Le modafinil est un agent favorisant l'Г©veil, et on pense que ses effets sont particuliГЁrement rГ©pandus dans la rГ©gion cГ©rГ©brale des ganglions de la base, qui est responsable de l'Г©veil. La dose initiale recommandГ©e est de 100 mg chez les personnes souffrant d'insomnie et de 200 mg chez celles souffrant d'apnГ©e centrale du sommeil. Un surdosage de modafinil se produit lorsqu'une quantitГ© d'une substance supГ©rieure Г l'apport humain normal est ingГ©rГ©e. Dans les essais, le mГ©dicament s'est avГ©rГ© augmenter la vigilance et amГ©liorer la cognition. Il n'est pas clair si l'utilisation pendant la grossesse est sans danger. Le modafinil affecte ainsi les cycles de sommeil et de veille des cellules cГ©rГ©brales, diminuant les effets des hormones du sommeil, l'adГ©nosine et la noradrГ©naline, cette derniГЁre ayant un effet anxiolytique. L'insuffisance rГ©nale peut diminuer la demi-vie d'environ 50 %. Le modafinil Г©tait Г l'origine connu sous le nom de D-amphГ©tamine, en rГ©fГ©rence Г sa forme de dextroamphГ©tamine, mais est commercialisГ© depuis les annГ©es 1970 sous le nom de modafinil, qui est dГ©rivГ© du latin modum signifiant В« amer В», une rГ©fГ©rence au goГ»t amer de la drogue qui a ensuite Г©tГ© abordГ©. Jouvet et Jean Lafon et est chimiquement liГ© Г l'Г©phГ©drine, Г la mГ©thamphГ©tamine et Г la phenmГ©trazine. Des Г©tudes n'ont pas trouvГ© que le modafinil Г©tait utile pour les personnes souffrant d'insomnie. Elle affecte le niveau de dopamine, un neurotransmetteur impliquГ© dans le contrГґle de l'attention et de la motivation. La dose la plus efficace (interdite) est de 100 mg, bien que certaines personnes (lГ©gГЁrement) plus somnolentes seraient OK avec 50 mg, alors que les personnes moins endormies seraient OK avec 200 mg.
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Le modafinil est similaire à l'amphétamine en ce sens qu'il améliore la cognition et augmente l'éveil. Cela augmente la durée pendant laquelle le patient peut rester éveillé sans se fatiguer. Ces récepteurs dopaminergiques font l'objet de recherches sur l'utilisation possible du modafinil dans d'autres troubles. La dose recommandée est de 100 à 200 mg par jour, ou de 2 à 400 mg par jour chez les personnes ayant des antécédents de troubles respiratoires liés au sommeil tels que l'apnée obstructive du sommeil. Pour certaines conditions, il peut être avantageux de commencer 5 à 10 heures avant le sommeil prévu. Il a été homologué pour la première fois en France en 1994. Le modafinil joue sur les zones du cerveau impliquées dans le cycle du sommeil, en particulier les noyaux locus coeruleus et subcoeruleus. Modafinil Ordonnance D'autres médicaments peuvent interagir avec le modafinil et augmenter ses effets secondaires. Le modafinil est également utilisé pour le traitement de certains types de dépression et comme aide à la perte de poids. Le modafinil est susceptible d'être utile aux utilisateurs récréatifs de ces substances car il augmente la vigilance et l'état d'éveil. C'est un analogue du neurotransmetteur dopamine. Le modafinil ne présente aucun risque significatif pour la santé. Ingrédient actif : Modafinil : l'ingrédient actif a la structure suivante. Le modafinil est également utilisé comme agent favorisant l'éveil. Il a été développé dans les années 1970 par le neurologue français Michel Jouvet et les Laboratoires Lafon, tous deux pionniers de la recherche des mécanismes du sommeil et de l'étude des troubles neurodégénératifs du cerveau. Le modafinil stimule les récepteurs D4. Le modafinil est un somnifère pharmacologique très efficace et un activateur de l'éveil.
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