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Il n'y a pas suffisamment de preuves pour dГ©terminer si l'utilisation de ce mГ©dicament a des effets nocifs. Modafinil est connu sous plusieurs noms commerciaux, notamment : Alertec, Armodafinil, Apprivia, Modavigil, Nuvigil et Provigil. Il s'agit d'un mГ©dicament gГ©nГ©rique, disponible en pharmacie en tant que gГ©nГ©rique de Provigil. Le modafinil peut ГЄtre pris avec ou sans nourriture. Il n'est pas recommandГ© chez les personnes souffrant d'arythmie, d'hypertension artГ©rielle importante ou d'hypertrophie ventriculaire gauche. Modafinil Ordonnance C'est une substance contrГґlГ©e aux Г‰tats-Unis. En particulier, le modafinil perturbe la capacitГ© de l'adГ©nosine Г  ralentir ou Г  arrГЄter l'activitГ© neuronale dans le cerveau et favorise ainsi l'Г©veil. Le modafinil semble agir en agissant sur la dopamine et en modulant les zones du cerveau impliquГ©es dans le cycle du sommeil. D'autres modes d'action plus thГ©oriques incluent la modulation des rГ©cepteurs GABA et de l'adГ©nosine, et l'inhibition de l'oxyde nitrique synthase. Cela aide le cerveau Г  libГ©rer plus d'acГ©tylcholine, ce qui rendrait le cerveau plus alerte. Lors de la sГ©lection d'un modafinil Г  vendre dans une pharmacie, il est important de choisir une marque qui a Г©tГ© Г©valuГ©e par la FDA. Le modafinil n'a aucun effet sur le corps ou le systГЁme cardiovasculaire, mais des Г©tudes ont suggГ©rГ© qu'il pourrait stimuler les neurotransmetteurs qui servent Г  libГ©rer un produit chimique dans le cerveau qui affecte l'AMP cyclique. Les versions gГ©nГ©riques du modafinil se sont avГ©rГ©es pharmacologiquement Г©quivalentes au nom de marque Provigil. En outre, il a Г©tГ© suggГ©rГ© que Modafinil agit en augmentant le niveau d'un neurotransmetteur appelГ© adГ©nosine. Il existe Г©galement un patch transdermique de modafinil. Le modafinil peut provoquer des effets secondaires chez les personnes souffrant de troubles du sommeil tels que l'apnГ©e du sommeil ou la narcolepsie. Il est utilisГ© hors AMM pour amГ©liorer l'Г©veil chez les adultes. Les patients prenant des mГ©dicaments qui inhibent le CYP3A4 (par exemple le kГ©toconazole) peuvent prГ©senter une diminution des effets secondaires. Le modafinil a Г©tГ© associГ© Г  des augmentations significatives de la frГ©quence cardiaque. C'est un inhibiteur actif, sГ©lectif et rГ©versible du transporteur de la dopamine (DA) et du transporteur de la noradrГ©naline (NE).

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Le modafinil bloque la recapture de la dopamine, ce qui augmente la dopamine disponible dans le systГЁme nerveux central. Le modafinil est susceptible d'augmenter les niveaux extracellulaires de dopamine dans la zone tegmentale ventrale du mГ©sencГ©phale, agissant pour activer les rГ©cepteurs de la dopamine sur les Г©pines D2 (dopamine-2). Il se solubilise facilement dans l'eau et est stable Г  tempГ©rature ambiante. Il n'est pas clair si l'utilisation pendant la grossesse est sans danger. Le modafinil peut Г©galement augmenter les effets de l'alcool et d'autres mГ©dicaments dГ©presseurs du SNC. La dopamine module le cycle du sommeil. Certains de ces effets peuvent Г©galement ГЄtre liГ©s Г  son antagonisme NMDA. Modafinil Ordonnance La FDA a publiГ© une lettre d'avertissement avertissant la sociГ©tГ© qui cherche Г  produire et Г  distribuer des comprimГ©s de modafinil. La dose typique recommandГ©e est de 100 Г  200 mg. Le principal effet du modafinil est une sensation d'Г©veil et souvent une vigilance accrue. Au Royaume-Uni, il s'appelle Modvigil. Les gГ©lules de modafinil sont disponibles en 40 mg, 200 mg, 400 mg et 600 mg. Le modafinil a Г©galement Г©tГ© proposГ© comme activateur cognitif. Le modafinil est un traitement de base pour les personnes souffrant de troubles du sommeil liГ©s au travail postГ© depuis 1999. Une augmentation supplГ©mentaire de la dose Г  200 mg peut ГЄtre nГ©cessaire chez les personnes qui ne prГ©sentent pas une diminution suffisante de la somnolence. S'il n'est pas pris le matin, il a tendance Г  perdre de son efficacitГ©. Le modafinil est un mГ©dicament stimulant utilisГ© pour traiter la somnolence due Г  la narcolepsie, les troubles du sommeil liГ©s au travail postГ© et l'apnГ©e obstructive du sommeil.

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