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Dans le traitement de la narcolepsie avec cataplexie, le modafinil est utilisГ© Г une dose de 100 Г 400 mg par jour. La quantitГ© de modafinil nГ©cessaire pour amГ©liorer la concentration et l'attention est gГ©nГ©ralement faible. Il est efficace pour rГ©duire la somnolence diurne et est Г©galement souvent utile pour rester vigilant pour les travailleurs postГ©s. En 2009, Guilhoto et al. On suppose que les effets stimulants du modafinil amГ©liorent les compГ©tences sociales et amГ©liorent l'intelligence. Modiodal Des doses supГ©rieures Г 400 mg ont Г©tГ© utilisГ©es avec le mГЄme niveau d'efficacitГ©. Le modafinil peut ГЄtre pris avant d'aller au lit ou pris le matin pour prГ©venir la somnolence diurne. Le modafinil a une demi-vie relativement courte d'environ 4 heures, en raison de la dГ©gradation de la molГ©cule de modafinil par mГ©thylation, hydroxylation et glucuronidation ultГ©rieure. Sa biodisponibilitГ© est d'environ 50 %. Le modafinil est connu pour stabiliser la respiration pendant un cycle de sommeil, prГ©venant ainsi la somnolence diurne excessive. Il a Г©tГ© approuvГ© pour un usage mГ©dical aux Г‰tats-Unis en 1998. Une revue de la littГ©rature disponible n'a cependant pas trouvГ© d'Г©tudes validant l'efficacitГ© hors AMM. Le modafinil est Г©galement disponible en gГ©lules et sous forme liquide, ce qui est plus pratique pour les enfants. Le modafinil est principalement utilisГ© pour augmenter la vigilance et amГ©liorer la concentration chez les personnes qui doivent rester Г©veillГ©es pendant une pГ©riode prolongГ©e, telles que les travailleurs postГ©s, les voyageurs ou les personnes qui doivent rester Г©veillГ©es pour Г©tudier. Le modafinil est un stimulant du systГЁme nerveux central (SNC) et agit principalement en se liant aux protГ©ines de transport des catГ©cholamines du cerveau pour augmenter les concentrations de ces neurotransmetteurs, notamment la noradrГ©naline et la dopamine. Il peut augmenter le risque de rГ©actions indГ©sirables Г l'alcool. En inhibant la dГ©gradation, une plus grande quantitГ© reste dans le cerveau. Une rГ©duction trop rapide de la dose peut entraГ®ner une rechute. Par consГ©quent, vous ne devez prendre Modafinil que tel que prescrit par votre mГ©decin.
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Dans les essais cliniques, les personnes prenant du modafinil dormaient en moyenne 50 Г 58 minutes de moins par nuit que les personnes prenant un placebo. Le modafinil, contrairement Г l'amphГ©tamine, n'est pas dГ©composГ© en substances plus actives par le mГ©tabolisme. Un examen de 2014 des Г©tudes sur les animaux a rГ©vГ©lГ© qu'il avait une efficacitГ© limitГ©e Г cette fin, mais un examen de 2017 des Г©tudes sur l'homme a rГ©vГ©lГ© que "le modafinil dГ©montre systГ©matiquement des effets cliniquement significatifs sur la vigilance, les performances cognitives et la fonction neuropsychologique". En plus d'amГ©liorer l'Г©veil, les gens ont Г©galement signalГ© des amГ©liorations de la performance mentale, de la motivation et de la vigilance. Le modafinil peut ГЄtre pris avec ou sans nourriture. Modafinil En Ligne Sans Ordonnance Le traitement par le modafinil augmente le sommeil Г ondes lentes (SWS) de plusieurs heures, ce qui rГ©duit le temps passГ© Г©veillГ© entre les Г©pisodes de sommeil, alors que d'autres types de mГ©dicaments ont souvent peu d'effet sur l'architecture du sommeil mais favorisent un sommeil plus profond. Pour soulager les symptГґmes de la somnolence diurne sГ©vГЁre dans la narcolepsie, le modafinil doit gГ©nГ©ralement ГЄtre pris plusieurs heures avant d'aller dormir et pris au besoin tout au long de la journГ©e. La marque la plus courante de Modafinil aux Г‰tats-Unis est Provigil. Le modafinil est une substance pharmacologiquement active dГ©rivГ©e de l'arbre fruitier Guajava (Cydonia oblonga). La plupart des gens ont besoin de trois ou quatre jours avant que leur mГ©dicament ne devienne efficace. On ne sait pas si l'utilisation chez les personnes souffrant de problГЁmes rГ©naux ou hГ©patiques est sans danger. Le modafinil est gГ©nГ©ralement prescrit pour une utilisation Г long terme. Le modafinil empГЄche l'adГ©nosine de se lier aux rГ©cepteurs cellulaires du cerveau, l'empГЄchant ainsi de se dГ©grader. Il augmente la frГ©quence et la durГ©e de l'Г©veil en amГ©liorant de maniГЁre sГ©lective la capacitГ© des neurones des centres de contrГґle principaux du cerveau Г synchroniser leur dГ©clenchement. Les formes posologiques spГ©cifiques approuvГ©es pour la narcolepsie comprennent le modafinil 100 mg en une seule dose quotidienne et le modafinil 200 mg deux fois par jour. Elle affecte plusieurs neurotransmetteurs, tels que la dopamine, la sГ©rotonine, la noradrГ©naline, ainsi que plusieurs zones du cerveau.
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