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Le modafinil est connu pour amГ©liorer les fonctions cognitives globales par rapport au placebo, bien que cela nГ©cessite une vГ©rification indГ©pendante supplГ©mentaire, car la plupart des Г©tudes se sont concentrГ©es sur ses effets en tant que traitement des troubles du sommeil. Le modafinil agit en inhibant la recapture de la dopamine dans les rГ©gions du cerveau oГ№ elle se trouve naturellement. Le modafinil a une longue demi-vie et est mГ©tabolisГ© relativement lentement. Le modafinil est non stimulant et non psychoactif et ne provoque pas de sensations d'euphorie ni d'autres effets secondaires courants des stimulants. Le modafinil est gГ©nГ©ralement pris une fois par jour, mais est disponible sous forme de comprimГ©s Г  des doses de 200 et 400 mg. Le modafinil est le stimulant le plus largement prescrit utilisГ© par les travailleurs postГ©s. C'est parce que Modafinil n'augmente pas les niveaux de neurotransmetteurs existants. Modalert Canada Dans le tableau ci-dessous, la posologie pour un adulte normal est prГ©sentГ©e. Le modafinil est un stimulant non amphГ©tamine Г  longue durГ©e d'action. Le deuxiГЁme centre chiral est en position 2. Le modafinil semble avoir peu d'effet sur le nombre de micro-Г©veils en sommeil paradoxal, bien qu'il puisse lГ©gГЁrement rГ©duire le nombre de micro-Г©veils SWS. Assurez-vous de prendre le modafinil Г  la mГЄme heure chaque jour et dans la mГЄme quantitГ©. Le principal ingrГ©dient pharmaceutique actif du modafinil est le N-acГ©tyl-d-aspartyl-d-glutamate (NAAG), bien que la concentration exacte de cet ingrГ©dient ne soit pas connue. On pense que le modafinil agit en augmentant les niveaux de dopamine, le neurotransmetteur associГ© Г  l'humeur, ainsi qu'en augmentant les niveaux d'acГ©tylcholine, un neurotransmetteur associГ© Г  l'Г©veil. il n'augmente pas le sentiment de vigilance. Il peut ГЄtre utilisГ© par des personnes en bonne santГ© pour soulager la somnolence et par des personnes souffrant de narcolepsie ou d'apnГ©e du sommeil qui souffrent de somnolence continue. Tenez votre mГ©decin au courant de tout nouveau mГ©dicament et de son utilitГ©. Il est probable que ces stimulants, qui agissent sur le SNC, bГ©nГ©ficient non seulement en amГ©liorant le nombre et la qualitГ© des cellules musculaires, en amГ©liorant le traitement de l'information et en crГ©ant une neuroplasticitГ©, mais aussi en facilitant la communication neuronale entre les rГ©gions du cerveau. Le modafinil est actuellement approuvГ© en Australie pour le traitement des troubles du sommeil liГ©s au travail postГ© et en Nouvelle-ZГ©lande pour les troubles du sommeil liГ©s au travail postГ© et le traitement de la somnolence excessive associГ©e Г  l'apnГ©e obstructive du sommeil.

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Provigil est Г©galement indiquГ© pour le traitement de la somnolence excessive associГ©e au trouble dГ©ficitaire de l'attention/hyperactivitГ© (TDAH). On ne sait pas si le modafinil affecte les malformations congГ©nitales, le dГ©veloppement fЕ“tal ou les fЕ“tus qui ont Г©tГ© exposГ©s au modafinil en laboratoire. Les effets durent 3 heures. Ces caractГ©ristiques le diffГ©rencient d'une benzodiazГ©pine traditionnelle. En fait, Modafinil est actuellement utilisГ© avec des mГ©dicaments qui sont principalement utilisГ©s pour le traitement de la dГ©pression, tels que l'imipramine, la dГ©sipramine et la dothiГ©pine. Modalert Canada Le nom chimique du modafinil est 7-(benzhydrylsulfinyl)1,2-dihydro-2,2-dimГ©thyl-1-pyrrolidinone. L'effet secondaire le plus courant est une sensation de fatigue ou de somnolence. Ses noms commerciaux incluent Armodafinil, Apo-Modafinil et Idafinil. Il n'est pas recommandГ© chez les personnes souffrant d'arythmie, d'hypertension artГ©rielle importante ou d'hypertrophie ventriculaire gauche. Le modafinil-SR a Г©tГ© associГ© Г  l'insomnie chez certains patients et est gГ©nГ©ralement prescrit Г  des doses de 150 Г  250 mg. Il est dГ©conseillГ© aux personnes prГ©sentant un dГ©ficit en G6PD. Il peut Г©galement interagir avec d'autres mГ©dicaments utilisГ©s pour traiter les troubles du sommeil. Chez des volontaires sains, le modafinil s'est avГ©rГ© meilleur que le placebo pour amГ©liorer les performances du test de performance continu (CPT) la nuit. La demi-vie du mГ©dicament est de sept Г  neuf heures, ce qui signifie que le dosage Г  l'Г©tat d'Г©quilibre est atteint aprГЁs un Г  deux jours d'administration. Si vous avez du mal Г  avaler, vous pouvez ouvrir un gГ©lule et descendre le gel sous forme de pilule. Il est Г©galement dГ©conseillГ© de l'utiliser pendant la grossesse. Ils dГ©priment le systГЁme nerveux central et peuvent causer de la somnolence. Le modafinil agit en amГ©liorant la dopamine et la neurotransmission noradrГ©nergique dans le cerveau. D'autres rГ©actions graves mais rares comprennent les hallucinations, les maux de tГЄte, les convulsions, les changements d'humeur et de comportement, la toxicomanie ou le sevrage.

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Dans de rares cas, des effets secondaires plus graves sont survenus, notamment des sautes d'humeur, de la confusion, des hallucinations et des délires. Le modafinil doit être utilisé en conjonction avec de la nourriture, car il peut entraîner une augmentation de la fréquence cardiaque chez les personnes à jeun. Dans les études animales, il a été démontré que le modafinil améliorait les performances cognitives dans des tests tels que la capacité à retenir des informations à l'esprit, l'attention et l'apprentissage. Le modafinil affecte principalement le SNC et il n'est pas recommandé chez les personnes souffrant de maladies cardiovasculaires, d'arythmies, d'hypertension ou d'insuffisance hépatique. Chez le rat, il a été démontré que le médicament augmente l'activité de la voie nigro-striée. La quantité maximale recommandée par jour est de 400 mg. Les tests d'urine ne sont pas recommandés comme moyen de surveiller les effets du modafinil dans le corps. Modalert Canada Le risque de dépendance est faible et peut être lié au mode de consommation. Le modafinil est utilisé dans le traitement des troubles du sommeil de la somnolence diurne excessive et des troubles du sommeil liés au travail posté, bien que ses mécanismes d'action ne soient pas bien compris. Le modafinil ne doit pas non plus être pris à jeun et il est recommandé de le prendre après au moins quatre heures de jeûne. Le modafinil a été développé dans les années 1970 par le neuroscientifique français Michel Jouvet et les laboratoires Lafon pour lutter contre la somnolence diurne. Le modafinil est un médicament d'ordonnance approuvé par la FDA pour le traitement de la narcolepsie et des troubles du sommeil liés au travail posté, ainsi que pour être utilisé comme stimulant cognitif chez les personnes en bonne santé. Étant donné que le modafinil est absorbé très rapidement, il est peu probable qu'il interagisse avec d'autres médicaments. Il ne réduit pas la fatigue comme c'est le cas avec les amphétamines, il ne produit pas la sensation euphorique de la cocaïne, il ne provoque pas de perte de poids, il ne provoque pas d'hypertension et il ne provoque pas d'augmentation du rythme cardiaque. Le modafinil n'est pas métabolisé par le CYP1A2, le CYP2D6, le CYP2E1, le CYP2C8 ou le CYP2C9. Cela signifie qu'il entre en compétition avec la sérotonine et la norépinéphrine pour une protéine (le transporteur) qui est nécessaire pour éliminer ces neurotransmetteurs de la synapse. Le modafinil est un médicament d'ordonnance qui comprend des effets favorisant l'éveil qui permettent un éveil soutenu. Les effets secondaires peuvent inclure des maux de tête, des nausées, des troubles du sommeil et une augmentation générale de l'activité. Le modafinil peut être utilisé pour les troubles du sommeil liés au travail posté.

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