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[Modafinil 200]

Le modafinil est un dérivé de la classe des benzodiazépines, un type de médicament connu pour ses effets relaxants. Le modafinil est un médicament stimulant utilisé pour traiter la narcolepsie, les troubles du travail posté et d'autres troubles du sommeil. En particulier, le modafinil perturbe la capacité de l'adénosine à ralentir ou à arrêter l'activité neuronale dans le cerveau et favorise ainsi l'éveil. Le nom chimique du chlorhydrate de modafinil est le chlorhydrate de 2-[(diphénylméthyl)sulfinyl]méthyl-2,3,4,5-tétrahydro-1H-1-benzazépin-7-ol. Le modafinil peut également provoquer l'apoptose de l'épithélium colique. Il a été fabriqué en ajoutant de la propylhexédrine à la lévodopa. Le modafinil peut provoquer des effets secondaires indésirables, notamment des maux de tête, des nausées, des étourdissements, de l'insomnie, de la toux, des douleurs abdominales, de l'irritabilité, de l'agitation et des troubles du sommeil. Modvigil En Ligne C'est dans les années 1980 qu'il a commencé à l'utiliser comme agent thérapeutique, mais Jouvet a écrit, "le modafinil n'a pas été à la hauteur des attentes". Développé par le Dr Michel Jouvet et le Pr Roland Lafon dans les années 1970, le modafinil a été initialement conçu comme un activateur de l'éveil. Jusqu'à présent, cependant, les essais cliniques sur le modafinil n'ont pas démontré de manière concluante son efficacité à court ou à long terme. Deux mécanismes différents contribuent probablement à l'inhibition de la libération de mélatonine par le modafinil : Le premier mécanisme implique l'inhibition de la transmission neuronale de la lumière. 400 et 600 mg de modafinil ont également réduit la somnolence excessive chez 64 % des participants à l'essai souffrant d'insomnie. Le nom chimique et la structure indiquent que Modafinil est un stimulant. Récemment, des rapports ont fait état d'une utilisation récréative généralisée du modafinil, soit comme ingrédient principal des boissons énergisantes, soit comme drogue de rue pour ses effets stimulants. Modafinil a été testé dans un certain nombre de groupes de sujets contrôlés par placebo, randomisés, en double aveugle, contrôlés par placebo et indépendants. Il doit également être utilisé avec prudence chez les personnes ayant des antécédents de réaction cutanée ou de réactions allergiques. Rarement, Modafinil peut provoquer des réactions cutanées sévères. Il ne semble pas provoquer d'allergie alimentaire ou alcoolique et il ne semble pas augmenter la tension artérielle ou rendre les patients plus sensibles aux infections. Le modafinil stimule le système noradrénaline, ce qui favorise l'éveil.

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Ainsi, l'utilisation rГ©guliГЁre de Modafinil est gГ©nГ©ralement sans danger et n'est pas associГ©e Г  l'abus de drogues. Le chlorhydrate de modafinil est une poudre cristalline blanche Г  blanc cassГ©. Il se lie au mГЄme site rГ©cepteur que les mГ©dicaments de type modafinil, le mГ©thylphГ©nidate, la phГ©nylГ©thylamine, l'amphГ©tamine et l'amino-benzazГ©pine adrafinil. Il n'est actuellement commercialisГ© pour aucun traitement autre que la narcolepsie ou les troubles du sommeil liГ©s au travail postГ©. En juillet 2016, la Food and Drug Administration (FDA) avait Г©mis une mise en garde contre l'utilisation du modafinil, dГ©clarant : В« Les femmes qui tombent enceintes pendant qu'elles prennent ces mГ©dicaments ne doivent pas allaiter. Les effets secondaires possibles du modafinil sont un potentiel de tolГ©rance et de dГ©pendance. Deux prГ©parations contiennent 600 mg, chaque comprimГ© contenant 150 mg de modafinil et les 450 mg restants d'ingrГ©dients inertes. Modvigil En Ligne Les femmes peuvent avoir un taux de mГ©tabolisme plus Г©levГ© et donc une demi-vie plus longue du modafinil par rapport aux hommes. DГ©veloppГ© Г  l'origine par les Laboratoires Lafon, une premiГЁre Г©tude (1976) a montrГ© que le sulfate de dextroamphГ©tamine (Dexedrine), un autre stimulant, Г©tait aussi efficace que le modafinil. Les partisans soutiennent que cela facilite la mГ©moire de travail. Cela peut amГ©liorer votre qualitГ© de vie. Le mГ©canisme d'action du modafinil est distinct de celui de l'amphГ©tamine. Le modafinil est gГ©nГ©ralement bien tolГ©rГ©. Modafinil a Г©tГ© Г©tudiГ© pour la sГ©curitГ© et l'efficacitГ©. Cette stimulation neurochimique amГЁne le corps Г  passer en mode "combat ou fuite", ce qui vous rend plus alerte. Banich Г  l'hГґpital McLean. Dans l'ensemble, on pense qu'environ 2% des personnes prГ©sentent des rГ©actions dermatologiques au modafinil. Les patients doivent ГЄtre Г©troitement surveillГ©s s'ils prennent ce mГ©dicament avec de l'alcool ou avec des mГ©dicaments sГ©datifs-hypnotiques. Il peut Г©galement ГЄtre dГ©rivГ© du phГ©nylacГ©tylcarbinol, un produit de dГ©gradation de la lignine. Il a Г©tГ© postulГ© que "l'Г©veil" peut impliquer deux mГ©canismes distincts : un mГ©canisme circadien-dГ©pendant dans les noyaux suprachiasmatiques de l'hypothalamus (SCN) et un entraГ®nement homГ©ostatique du mГ©tabolisme Г©nergГ©tique qui est plus constant et probablement moins sensible aux rythmes circadiens. La dose recommandГ©e est celle d'un traitement pour la journГ©e (par opposition Г  la durГ©e d'une journГ©e spГ©cifique) car une dose unique de plus de 200 mg peut entraГ®ner une perte de contrГґle. Ils sont gГ©nГ©ralement pris environ une heure avant le coucher.

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[Modafinil 200]

Le modafinil est utilisГ© mГ©dicalement depuis la fin des annГ©es 1970 pour traiter la somnolence excessive liГ©e Г  la narcolepsie ou aux troubles du sommeil liГ©s au travail postГ© et s'appelait Г  l'origine Armodafinil. Le modafinil est le composant actif de l'aide au sommeil hors AMM Provigil, fabriquГ© par Cephalon. Cela signifie que ce mГ©dicament affecte le cerveau, lГ  oГ№ les cycles de sommeil et d'Г©veil sont contrГґlГ©s. Il peut aider les patients atteints de narcolepsie, de troubles du sommeil liГ©s au travail postГ© et d'apnГ©e obstructive du sommeil grГўce Г  ses effets sur un certain nombre de neurotransmetteurs dans le cerveau, mais son mГ©canisme d'action exact est inconnu. Il peut Г©galement ГЄtre utile dans le traitement des troubles du sommeil. Modvigil En Ligne Le modafinil est un analogue mГ©thylГ© de l'adГ©nosine. Le modafinil a d'abord Г©tГ© dГ©veloppГ© par le pharmacologue clinicien Michel Jouvet et dГ©couvert par les Laboratoires Lafon. La Food and Drug Administration a approuvГ© le modafinil pour le traitement des troubles du travail postГ© aux Г‰tats-Unis. Le modafinil n'a aucun effet sur le mГ©tabolisme d'autres mГ©dicaments, tels que la warfarine ou la phГ©nytoГЇne, et il n'affecte pas les taux d'enzymes hГ©patiques. Des doses trop Г©levГ©es de modafinil sont connues pour stimuler l'appГ©tit et une insomnie peut survenir si une trop grande quantitГ© est prise trop tГґt dans la journГ©e. Le modafinil peut Г©galement augmenter ou diminuer la tension artГ©rielle. Le modafinil est le seul mГ©dicament approuvГ© par la FDA pour le traitement de l'apnГ©e obstructive du sommeil. Il est peu probable qu'il devienne un traitement standard, bien que pour ceux qui prГ©sentent des symptГґmes graves, il a Г©tГ© dГ©montrГ© qu'il amГ©liore le fonctionnement du patient. Le traitement par le modafinil peut ГЄtre bГ©nГ©fique pour certains cas de somnolence associГ©s Г  une surmГ©dication ou Г  une sous-mГ©dication avec des antidГ©presseurs, des sГ©datifs, des antihistaminiques et des antipsychotiques. Son utilisation aux Г‰tats-Unis n'a Г©tГ© approuvГ©e pour aucune indication clinique.

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