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[Modafinil 200]

La grossesse et l'allaitement sont contre-indiquГ©s, car le modafinil est connu pour perturber les cycles de sommeil maternels. Certains utilisateurs ont Г©tГ© signalГ©s Г  utiliser deux comprimГ©s de 100 mg par jour. Les stimulants du SNC sont une classe de mГ©dicaments largement utilisГ©s pour traiter les problГЁmes de somnolence et d'Г©veil. Il a Г©tГ© dГ©montrГ© que le modafinil augmente la monoamine oxydase A (MAOA), une enzyme impliquГ©e dans le mГ©tabolisme de la dopamine. Cela ne fait pas arrГЄter quelqu'un de respirer. Les effets du modafinil sont observГ©s en 30 minutes environ, les premiers effets notables sur la vigilance survenant environ 1 heure aprГЁs la prise de la dose. L'hydroxy-modafinil est le principal mГ©tabolite trouvГ© dans l'urine, tandis que la phГ©nacГ©tine conjuguГ©e et sa forme Г©nol inactive sont excrГ©tГ©es dans l'urine. Achat Modafinil Le modafinil est efficace en aussi peu que 3 mois d'utilisation. Le mГ©dicament est disponible uniquement sur ordonnance. Il n'a jamais Г©tГ© approuvГ© pour la vente aux Г‰tats-Unis. Il s'agit d'un mГ©lange racГ©mique de deux stГ©rГ©oisomГЁres, le R-modafinil et le S-modafinil, qui sont formГ©s dans le corps Г  partir de la mГЄme molГ©cule de dГ©part mais qui diffГЁrent par leur forme et leurs propriГ©tГ©s. Cependant, certains utilisateurs de la drogue n'ont signalГ© aucun changement significatif dans la cognition, tandis que d'autres ont souffert d'une aggravation des symptГґmes ou d'un dysfonctionnement mental accru. C'est un mГ©dicament sympathomimГ©tique qui favorise l'Г©veil en augmentant les niveaux d'Г©pinГ©phrine et de noradrГ©naline dans le cerveau. Ses effets sont immГ©diats, avec un effet maximal aprГЁs une Г  trois heures, et une concentration maximale dans le sang aprГЁs deux heures. Le modafinil s'est avГ©rГ© ГЄtre un antagoniste compГ©titif sГ©lectif des rГ©cepteurs de l'adГ©nosine chimique favorisant l'Г©veil, le mГЄme type de mГ©canisme que celui utilisГ© par les benzodiazГ©pines. Pour la narcolepsie, elle peut ГЄtre aussi faible que 100 mg par jour, tandis que pour l'insomnie, elle peut aller jusqu'Г  200 mg par jour. Ne pas l'Г©craser ni le mГўcher.

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Les essais cliniques avec une utilisation Г  long terme du modafinil et les rГ©sultats concernant sa sГ©curitГ© sont limitГ©s. Comme les autres mГ©dicaments gГ©nГ©riques, il a la mГЄme fonction que le mГ©dicament de marque. Le modafinil n'est dГ©livrГ© que sur ordonnance. C'est un psychostimulant, ce qui signifie qu'il agit en augmentant l'effet du neurotransmetteur dopamine dans le cerveau, qui est impliquГ© dans le plaisir et d'autres processus mentaux. Le mГ©canisme d'action exact du modafinil n'est pas bien connu. Achat Modafinil somnolence du grand public. Une revue de 2009 de la littГ©rature existante sur le modafinil a conclu que les preuves ne soutiennent pas l'utilisation du modafinil pour l'amГ©lioration gГ©nГ©rale du fonctionnement cognitif. Pour que le modafinil exerce son effet, il doit d'abord traverser la barriГЁre hГ©mato-encГ©phalique et peut ГЄtre facilement identifiГ© par l'utilisation de la tomographie par Г©mission de positrons. Sa formule chimique est C20H22N4O. Le matГ©riel disponible sur les ressources en ligne, y compris certains sites non autorisГ©s, dГ©crit le modafinil comme une aide cognitive amГ©liorГ©e, un stimulant et un modulateur des rythmes circadiens. Le modafinil peut Г©galement provoquer une arythmie ou une hypertension. Le modafinil est bien absorbГ© aprГЁs administration orale, avec des concentrations sanguines maximales survenant 1 Г  3 heures aprГЁs l'ingestion. Il a toujours une activitГ© d'agoniste partiel sur le rГ©cepteur GABAA, avec une CE50 d'environ 4 mg/L. CommercialisГ© sous le nom de Provigil aux Г‰tats-Unis, le modafinil est actuellement disponible uniquement sur ordonnance. Les effets indГ©sirables du modafinil comprennent des maux de tГЄte, des difficultГ©s Г  s'endormir ou Г  rester endormi, des nausГ©es et des vomissements, et mГЄme des nausГ©es. п»їAu niveau molГ©culaire, le modafinil est une benzazГ©pine substituГ©e structurellement similaire au mГ©dicament anti-narcoleptique d-amphГ©tamine, qui a la structure benzyl-indol-5-yl. Une action de type amphГ©tamine a conduit Г  spГ©culer que le modafinil est similaire Г  d'autres mГ©dicaments stimulants. Cela n'a pas interfГ©rГ© avec le goГ»t, mais la teneur en cafГ©ine a Г©tГ© rГ©duite de 150 mg Г  140 mg et la dose de modafinil a Г©tГ© augmentГ©e de 100 mg Г  200 mg. Seul un petit pourcentage des doses prises par les personnes ne produit aucun effet. Aux Г‰tats-Unis, le modafinil est approuvГ© pour une utilisation dans les troubles du sommeil liГ©s au travail postГ©, ainsi que pour le traitement Г  court terme des symptГґmes diurnes de la narcolepsie.

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[BrandonUttet]

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