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Il est gГ©nГ©ralement administrГ© Г  des doses de 100 Г  200 mg, mais comme pour les autres stimulants, la posologie peut ГЄtre augmentГ©e ou diminuГ©e en fonction des symptГґmes. Le modafinil est utilisГ© pour traiter divers troubles du sommeil et la fatigue diurne, tels que les troubles du sommeil liГ©s au travail postГ© (SWSD), l'apnГ©e du sommeil, la narcolepsie et la cataplexie; les effets secondaires Г  court terme peuvent inclure des maux de tГЄte, des troubles du sommeil et des nausГ©es. Il se prГ©sente sous les formes gГ©nГ©riques et de marque. Le modafinil agit en augmentant la libГ©ration des neurotransmetteurs dopamine, noradrГ©naline et sГ©rotonine. Le modafinil semble stimuler le systГЁme nerveux central en stimulant les cellules cГ©rГ©brales. Nootropique En France п»їLe modafinil est un stimulant du systГЁme nerveux central. Le modafinil est prescrit dans le traitement de la somnolence excessive associГ©e Г  la narcolepsie et Г  l'hypersomnie idiopathique. Bien qu'une telle inhibition puisse thГ©oriquement augmenter les concentrations plasmatiques d'un deuxiГЁme mГ©dicament, la signification clinique de l'interaction n'est pas claire. Il est gГ©nГ©ralement pris 2 Г  3 heures avant le coucher comme traitement de la somnolence, bien qu'une utilisation une fois par jour ou moins frГ©quente soit Г©galement connue pour augmenter la vigilance. Le modafinil affecte les neurotransmetteurs noradrГ©naline, dopamine et sГ©rotonine, entre autres. Il existe peu d'informations sur les effets Г  long terme de l'utilisation de Modafinil. Le modafinil est disponible Г  la fois comme mГ©dicament en vente libre et comme mГ©dicament sur ordonnance. Le modafinil est mГ©tabolisГ© par glucuronidation, la conjugaison du mГ©dicament actif avec l'acide glucuronique. Il peut Г©galement interagir avec d'autres mГ©dicaments utilisГ©s pour traiter les troubles du sommeil. En Europe, il est approuvГ© pour la cataplexie, une somnolence excessive d'origine mГ©dicamenteuse. Le modafinil peut Г©galement ГЄtre utilisГ© pour stimuler la vigilance chez les personnes atteintes de narcolepsie. Le modafinil augmente l'efficacitГ© de l'orexine naturelle (hormone rГ©gulatrice du sommeil par mouvements oculaires non rapides), qui est en grande partie synthГ©tisГ©e dans le locus coeruleus et libГ©rГ©e pendant le sommeil. Prendre du modafinil le matin ou pendant la journГ©e est moins efficace. Chez l'homme, le modafinil est utilisГ© Г  des doses allant de 200 mg Г  400 mg inclus.

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D'autres médicaments peuvent inhiber les effets du modafinil et amplifier leurs effets. Aux États-Unis, il est approuvé en comprimés de 10 mg et 25 mg. Les laboratoires Jouvet et Lafon étaient les développeurs originaux du modafinil. Il a également été noté que le modafinil bloque en fait les effets de l'adénosine sur les récepteurs de l'adénosine A2A en bloquant l'effet de l'adénosine sur les récepteurs A2A et en empêchant le récepteur de transférer son message à la cellule induisant l'éveil. En 2013, le fabricant d'origine Sun Pharmaceutical Industries a été contraint de rappeler des lots de médicaments modafinil des étagères des pharmacies après qu'il ait été lié à de nombreux rapports sur les effets secondaires de la psychose et du délire chez les utilisateurs chroniques, selon des rapports dans le Journal de médecine de la Nouvelle-Angleterre. Le terme était une pièce de théâtre sur le nom de Modred, un personnage masculin de la romance médiévale de Roger Lancelyn Green, The Faerie Queene, qui est à la base de la première ligne de la phrase Modred's revenge. Il se compose de 150 mg, 300 mg ou 400 mg de l'ingrédient actif modafinil (C8H7NO2 actif). Nootropique En France Le modafinil est généralement bien toléré par la plupart des gens, bien que plus de 30 % des gens éprouvent des effets secondaires qui peuvent inclure des nausées, des vomissements, de la diarrhée, des douleurs à l'estomac, des maux de tête, des troubles du sommeil et de la confusion. Les plus grands essais d'efficacité ont des doses comprises entre 200 mg et 400 mg. Le modafinil est un faible inhibiteur de la recapture de la noradrénaline. Certaines études suggèrent que le modafinil pourrait être efficace pour améliorer la somnolence non liée au quart de travail causée par l'insomnie d'endormissement. Lorsqu'il est utilisé pour traiter cela, le modafinil agit en augmentant les niveaux de caféine, de théophylline et d'autres agents dans le cerveau. Le modafinil peut causer de l'anxiété, de l'agitation et des maux de tête. Les effets secondaires rares et graves peuvent inclure des arythmies telles qu'une fréquence cardiaque anormale et un allongement de l'intervalle QT, ainsi qu'une ischémie myocardique (cardiopathie ischémique ou arrêt cardiaque). À un moment donné, les 400 mg avaient des prix de détail de 66 $ par comprimé. Le modafinil est absorbé par les muqueuses de la cavité buccale, mais pas à travers la peau. Les patients prenant du modafinil comme alternative ou complément à un somnifère signalent généralement une augmentation de l'énergie et de la vigilance, tandis que d'autres signalent une amélioration de la concentration et de la capacité de concentration. Une méta-analyse de ces essais a suggéré que le modafinil est un traitement efficace pour l'amélioration cognitive chez les personnes en bonne santé.

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