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Le mГ©canisme d'action proposГ© du modafinil est l'inhibition de l'endormissement et de l'Г©veil mГ©diГ©e par l'inhibition d'un rГ©seau neuronal spГ©cifique favorisant l'Г©veil dans l'hypothalamus. Le modafinil agit directement sur le cerveau pour augmenter l'Г©veil. Avant de prendre le mГ©dicament, assurez-vous d'Г©crire une liste de tous les mГ©dicaments que vous prenez. Une autre substance indolГ©amine, la mГ©thamphГ©tamine, est commercialisГ©e sous une licence similaire Г celle de Provigil. Le modafinil est Г©galement un agoniste plus puissant des rГ©cepteurs D1 et D2 que la dopamine. Il n'est pas recommandГ© chez les personnes souffrant d'arythmie, d'hypertension artГ©rielle importante ou d'hypertrophie ventriculaire gauche. Elle est causГ©e par l'activitГ© d'un neurotransmetteur (acГ©tylcholine) dans la moelle Г©piniГЁre. Acheter Modiodal Generique Il est utilisГ© dans le traitement de la somnolence excessive, des troubles du sommeil/Г©veil, des troubles du sommeil tels que la narcolepsie et l'apnГ©e obstructive du sommeil, et des troubles du sommeil liГ©s au travail postГ©. La dose peut ГЄtre augmentГ©e de 200 Г 400 mg jusqu'Г l'obtention de l'effet souhaitГ©. Des Г©tudes en laboratoire sur des animaux montrent que le modafinil augmente les niveaux de noradrГ©naline dans le cerveau en bloquant l'absorption neuronale de noradrГ©naline Г partir de l'espace extracellulaire. De tels Г©vГ©nements surviennent plus frГ©quemment chez les patients ayant des antГ©cГ©dents d'hypertension ou de diabГЁte. La biodisponibilitГ© du modafinil oral est supГ©rieure Г 98 % et la biodisponibilitГ© absolue est d'environ 99 %. Le modafinil est Г©galement un ingrГ©dient actif d'autres mГ©dicaments contre les troubles du sommeil, notamment Armodafinil, Nuvigil et Avigil, qui sont des mГ©dicaments sur ordonnance utilisГ©s pour traiter respectivement les troubles du sommeil liГ©s au travail postГ©, l'apnГ©e obstructive du sommeil et la narcolepsie. Il y a beaucoup de spГ©culations concernant la raison biologique de cet effet. Le modafinil est gГ©nГ©ralement pris 400 mg avant le coucher. Le modafinil n'est actuellement pas approuvГ© au Royaume-Uni pour l'insomnie, bien qu'il ait Г©tГ© utilisГ© dans certains essais sur l'utilitГ© des ISRS dans le traitement de l'insomnie. Chez les personnes atteintes de narcolepsie, on pense que le modafinil agit pour dГ©synchroniser le sommeil paradoxal, empГЄchant la somnolence pendant les rГЄves. Alors que le Modafinil est classГ© comme un stimulant du SNC, il n'y a qu'une seule action connue du Modafinil sur le SNC.
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Il agit en augmentant l'Г©veil et peut amГ©liorer la latence du sommeil, ainsi qu'en ayant une incidence rapportГ©e plus faible de comportements anormaux et d'hallucinations induites par le sommeil par rapport Г d'autres mГ©dicaments stimulants. Il peut Г©galement agir directement sur les neurones dopaminergiques du systГЁme mГ©solimbique. La quantitГ© de mГ©dicament utilisГ©e peut devoir ГЄtre ajustГ©e chez les personnes souffrant de problГЁmes rГ©naux ou hГ©patiques. Le niveau d'action du modafinil sur l'acГ©tylcholine est similaire Г celui du donГ©pГ©zil (Aricept) et de la mГ©mantine. Ce mГ©canisme d'action diffГ©rent explique pourquoi le modafinil ne produit pas la nervositГ© communГ©ment associГ©e aux stimulants. Il fonctionne chez les personnes qui manquent modГ©rГ©ment de sommeil ou qui se sentent trГЁs somnolentes. En plus de ses indications approuvГ©es, Modafinil est approuvГ© dans de nombreux autres pays pour le traitement de la somnolence diurne excessive rГ©sultant d'une condition mГ©dicale. Acheter Modafinil Sans Ordonnance Le modafinil est vendu comme substance contrГґlГ©e dans la plupart des pays. Il peut ГЄtre pris seul ou sous forme de mГ©dicament combinГ©, connu sous le nom de modafinil modafinil. Les essais cliniques n'ont Г©galement trouvГ© aucune diffГ©rence significative entre les groupes prenant du modafinil et un placebo pour amГ©liorer la vigilance et la fonction diurne chez les travailleurs postГ©s. Le modafinil ne doit pas ГЄtre pris plus d'une fois par jour Г fortes doses, il est donc gГ©nГ©ralement utilisГ© Г faible dose. Le modafinil est pris par voie orale et est classГ© comme agent sГ©lectif favorisant l'Г©veil. Le modafinil augmente l'Г©veil, rГ©duit la fatigue, amГ©liore la concentration, augmente la vigilance et amГ©liore le sentiment de vigilance mentale. Le modafinil est un mГ©dicament utilisГ© pour le traitement de la somnolence excessive associГ©e Г la narcolepsie. Le modafinil et les mГ©dicaments liГ©s au modafinil sont interdits dans la Major League Baseball. Jouvet croyait que le mГ©dicament Г©tait capable de rendre les gens plus alertes et plus capables d'apprendre. L'effet du modafinil peut ГЄtre diminuГ© pendant les pГ©riodes d'activitГ© physique. L'utilisation principale du modafinil est de traiter les symptГґmes des troubles du sommeil.
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