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C'est également un agent nootropique, ou améliorant la cognition, améliorant la synthèse du neurotransmetteur dopamine, qui est responsable de certains aspects de la mémoire, de l'apprentissage et de la motivation. Le modafinil a été développé pour la première fois comme traitement de la narcolepsie dans les années 1970 par le neuroscientifique français Michel Jouvet et les laboratoires Lafon. Il est substitué en C-4 et on pense qu'il est plus stable que la l-Dopa. En inhibant la recapture de la norépinéphrine et de l'acétylcholine et en augmentant la libération synaptique des neurotransmetteurs glutamate et dopamine, le modafinil a des effets stimulants. Il s'agit d'un médicament délivré uniquement sur ordonnance aux États-Unis. Nootropique Pharmacie Le modafinil est un stimulant du système nerveux central, également appelé psychostimulant ou stimulant non amphétamine. Certains experts pensent que le modafinil agit en augmentant la libération de dopamine et de sérotonine dans le cerveau. Cela devrait être fait avant de l'utiliser pendant plus de quelques jours, cependant, afin d'éviter tout problème. Contrairement à d'autres agents favorisant l'éveil, le modafinil n'est pas une catécholamine. Le médicament a réussi à plus de 90% à modifier les habitudes de sommeil des patients atteints de narcolepsie et était, à l'époque, l'un des premiers médicaments à avoir réussi à traiter ce trouble. Le modafinil n'a aucun effet sur le corps ou le système cardiovasculaire, mais des études ont suggéré qu'il pourrait stimuler les neurotransmetteurs qui servent à libérer un produit chimique dans le cerveau qui affecte l'AMP cyclique. Il a ensuite été approuvé pour un usage médical en Europe et au Canada en 1994. Le nom chimique du modafinil est 2-(2-benzylpyrrolidin-3-yl)-[1,2,4]triazolo[4,3-b]pyridazine et son poids moléculaire est de 372,69. Le modafinil est également utilisé pour améliorer l'éveil chez certaines personnes qui ne souffrent pas de somnolence diurne excessive. Il est commercialisé en France sous le nom de marque Modafinil, et en Australie et aux États-Unis sous le nom de marque Provigil. Les enzymes CYP1A2 et 3A4 ont des rôles mineurs.
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On pense que cela est dГ» Г son action sur le systГЁme nerveux central. Le modafinil a Г©tГ© testГ© pour sa toxicitГ© chez la souris et pour un certain nombre d'utilisations thГ©rapeutiques diffГ©rentes. Il peut amener certaines personnes Г se sentir modГ©rГ©ment ou trГЁs alerte, et il peut Г©galement rГ©duire les effets de l'alcool. Le modafinil appartient Г un groupe de mГ©dicaments appelГ©s psychostimulants, qui comprend l'amphГ©tamine, la cocaГЇne et le mГ©thylphГ©nidate. Son mГ©canisme d'action n'a pas Г©tГ© Г©tabli, mais ce n'est pas un inhibiteur de la recapture de l'adГ©nosine. Ceux qui sont diabГ©tiques peuvent le prendre avec un repas. Nootropique Pharmacie Il a Г©tГ© approuvГ© comme traitement des conditions favorisant l'Г©veil aux Г‰tats-Unis en 1998 et pour le traitement des travailleurs postГ©s en Europe en 1994. Des doses rГ©guliГЁres de modafinil peuvent Г©galement augmenter la pression artГ©rielle et la frГ©quence cardiaque. Cela peut ГЄtre un risque particulier chez les patients pГ©diatriques. Cependant, le modafinil est approuvГ© comme mГ©dicament d'ordonnance pour le traitement de l'insomnie, de la somnolence diurne excessive liГ©e Г l'apnГ©e du sommeil, de la narcolepsie et des troubles du sommeil liГ©s au travail postГ©. Les comprimГ©s contiennent le mГ©dicament actif ModalertВ®. Le modafinil agit comme un inhibiteur de la recapture de l'adГ©nosine (ATP), ce qui en fait un stimulant "favorisant l'Г©veil". Le modafinil peut interagir avec la neurotransmission sГ©rotoninergique et inhiber la recapture de la sГ©rotonine. Dans des Г©tudes animales utilisant des primates, il a Г©tГ© dГ©montrГ© que le modafinil augmente la dopamine dans le cerveau. Il a Г©tГ© dГ©montrГ© que le modafinil est actif dans des modГЁles d'activitГ© psychostimulante et de potentiel d'abus chez le rat et le primate. Les doses de 300 mg et 400 mg sont gГ©nГ©ralement prises deux fois par jour. Les autres membres de la famille comprennent la cafГ©ine, les amphГ©tamines et le mГ©thylphГ©nidate. Bien qu'il puisse ГЄtre utilisГ© dans le traitement de la narcolepsie, la recherche clinique n'est pas concluante, mГЄme s'il s'agit du seul mГ©dicament actuellement disponible pour le traitement de la narcolepsie. Le modafinil est une poudre cristalline blanche Г blanc cassГ© au goГ»t amer. Le modafinil est Г©galement un antagoniste faible des rГ©cepteurs de la sГ©rotonine, mais il peut ГЄtre plus sГ©lectif que tous les autres agents actuellement disponibles, car il n'antagonise pas le rГ©cepteur aux concentrations thГ©rapeutiques.
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01-04-2023, 06:19 PM
(This post was last modified: 01-04-2023, 06:20 PM by BrandonUttet.)
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