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Les quantitГ©s quotidiennes prises peuvent devoir ГЄtre augmentГ©es. Le modafinil est mГ©tabolisГ© principalement par l'enzyme CYP3A4 dans le foie et l'intestin grГЄle. Le modafinil est utilisГ© pour traiter les troubles de la somnolence tels que la narcolepsie et les troubles du sommeil liГ©s au travail postГ©. La forme active du modafinil est le R-(-)-2-[(diphГ©nylmГ©thyl)sulfinyl]acГ©tamide, et la formule chimique du modafinil est C14H14ClNO2S. Il est pris une fois par jour au coucher. Le modafinil semble activer ces zones cГ©rГ©brales avec moins d'effets secondaires que l'amphГ©tamine et d'autres agents favorisant l'Г©veil. Le modafinil a Г©tГ© utilisГ© pour le traitement du TDAH, en particulier chez les enfants et chez les adultes souffrant de troubles du sommeil liГ©s au travail postГ©. Certaines personnes peuvent avoir un appГ©tit accru ou des troubles du sommeil avec des doses plus Г©levГ©es. La stimulation de ces rГ©cepteurs produit un Г©tat d'Г©veil qui dure au moins 2,5 heures. Le modafinil est un dГ©rivГ© de la phГ©nГ©thylamine ou un dГ©rivГ© d'alcyne. Il est Г©galement disponible en tant que mГ©dicament gГ©nГ©rique. Provigil En Maroc Le modafinil n'est pas indiquГ© pour le traitement de la narcolepsie. Le modafinil est un mГ©dicament appartenant aux classes de mГ©dicaments nootropiques et hypnotiques. 50 mg peuvent ГЄtre pris juste avant une activitГ© d'amГ©lioration cognitive. L'amГ©lioration cognitive (l'utilisation d'un mГ©dicament pour stimuler la cognition) est devenue un sujet de discussion populaire. Il reste Г dГ©terminer si le rГ©cepteur de la dopamine liГ© Г l'action du Modafinil est le rГ©cepteur D1 ou D2. Les effets du modafinil peuvent ГЄtre dus Г son interaction avec les voies de neurotransmission de la dopamine en augmentant l'Г©veil et en diminuant la somnolence. La dose initiale recommandГ©e de modafinil est de 200 mg pris une fois par jour avant le coucher. Cette Г©tude a conclu que la pГ©moline n'Г©tait pas un activateur cognitif efficace. La narcolepsie a une base gГ©nГ©tique et n'est pas connue pour ГЄtre contagieuse. Il ne semble pas ГЄtre un traitement efficace pour la somnolence excessive due Г l'apnГ©e obstructive du sommeil. Ceux qui allaitent devraient consulter leur mГ©decin avant de le prendre. Le modafinil cible les transporteurs GABA et noradrГ©naline pour aider la fonction neuronale. Les interactions sont rГ©sumГ©es par pharmacologie clinique et thГ©rapeutique.
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Cependant, certaines Г©tudes ont montrГ© qu'il amГ©liorait le fonctionnement mental et augmentait la productivitГ©. Le modafinil est disponible sous de nombreuses formes, notamment des comprimГ©s de 100 mg, des comprimГ©s de 200 mg, des comprimГ©s de 400 mg et des comprimГ©s Г libГ©ration prolongГ©e de 200 mg. Les psychostimulants sont des mГ©dicaments qui augmentent les concentrations de noradrГ©naline et de dopamine dans le cerveau. Le modafinil, Г©galement disponible sous forme Г libГ©ration prolongГ©e et sous forme Г libГ©ration prolongГ©e, est un agent Г action centrale qui amГ©liore l'Г©veil. Cependant, il existe des preuves que cela peut provoquer une augmentation des sentiments de paranoГЇa et d'anxiГ©tГ©, et des cauchemars plus frГ©quents, chez certaines personnes. Le modafinil est un sel de chlorhydrate (HCL) de 2-benzyl-2-(diphГ©nylmГ©thyl)-1,3-propanediol (ou chlorhydrate de 2-benzyl-2-(diphГ©nylmГ©thyl)-1,3-propanediol) et a un poids molГ©culaire de 314,49 g/mol. Il a Г©tГ© rapportГ© que le modafinil augmente l'Г©veil et amГ©liore les performances cognitives chez les travailleurs de nuit. Le modafinil est disponible en tant que mГ©dicament gГ©nГ©rique et sous diffГ©rentes formes, notamment un comprimГ©, une pilule, une gomme, un spray nasal et une solution. Il est disponible sous les noms Citalopram Modafinil (Modalert), Citadine 100mg Modafinil (Citidin), Modafinil-Hcl (Provigil), Modafinil (Provigil-Hcl) et Modafinil (Aricept). Le modafinil est Г©galement utilisГ© pour traiter la narcolepsie, qui est une maladie extrГЄmement dГ©bilitante caractГ©risГ©e par des cycles de sommeil anormaux qui amГЁnent les patients Г s'endormir Г des moments inappropriГ©s de la journГ©e. Le modafinil n'est pas une substance contrГґlГ©e aux Г‰tats-Unis et est disponible sans ordonnance. Nootropique En France Le modafinil reste fonctionnel aprГЁs la production d'amphГ©tamine ; il agit en augmentant l'Г©veil et n'a pas d'effets semblables Г ceux des amphГ©tamines. Bien que le mГ©canisme d'action exact du modafinil ne soit toujours pas clair, le mГ©canisme d'action du modafinil comprend la modulation des rГ©cepteurs cholinergiques et dopaminergiques, ainsi que l'augmentation des niveaux d'adГ©nosine dans le cerveau. Cependant, la forme de Modafinil pour une utilisation en vente libre (OTC) contient 200 mg, tandis que celle utilisГ©e pour la recherche et approuvГ©e pour une utilisation aux Г‰tats-Unis est de 400 mg. L'Г©nantiomГЁre unique s'est avГ©rГ© efficace dans les Г©tudes animales ainsi que chez l'homme. Certains experts pensent que le modafinil agit en augmentant la libГ©ration de dopamine et de sГ©rotonine dans le cerveau. Chez les personnes atteintes de narcolepsie, le modafinil est utilisГ© pour rГ©duire la somnolence. Son mГ©canisme d'action exact est inconnu, mais on pense qu'il interfГЁre avec les neurones favorisant l'Г©veil dans le tronc cГ©rГ©bral. Le mГ©dicament est le seul traitement disponible dans le commerce pour la narcolepsie. Le mГ©dicament est parfois pris par des mГ©decins Г des doses plus faibles (200 Г 400 mg) pendant de longues pГ©riodes. Il n'est pas recommandГ© chez les personnes souffrant de bradycardie, de thyrotoxicose ou d'hypertension artГ©rielle. L'amphГ©tamine est plus puissante que la lГ©vodopa car elle a un effet plus direct sur la libГ©ration de dopamine.
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Le modafinil est prГ©sentГ© dans un flacon de 60 gГ©lules. Le modafinil, ainsi que d'autres stimulants, agit en augmentant la quantitГ© de dopamine libГ©rГ©e dans le cerveau. Le modafinil est le plus souvent prescrit sous forme de dose unique, mais il peut ГЄtre utilisГ© dans un schГ©ma fractionnГ© avec d'autres stimulants pour maintenir la tempГ©rature corporelle basse. Le modafinil est un nouveau mГ©dicament et tous les mГ©decins et pharmaciens ne sont pas conscients de ses effets secondaires possibles. Lors de tests en laboratoire, il a Г©tГ© constatГ© que le Modafinil amГ©liorait la mГ©moire et la performance aux tests de vigilance et de compГ©tences psychomotrices, y compris les tests impliquant l'attention, la planification, l'attention, la prise de dГ©cision et l'apprentissage autonome. Il fait partie des meilleurs candidats pour devenir un mГ©dicament destinГ© Г amГ©liorer les performances cognitives. Une Г©tude suggГЁre que le modafinil amГ©liore les performances des rats de laboratoire sur les tГўches qui nГ©cessitent de la mГ©moire. Un surdosage de modafinil se produit lorsqu'une quantitГ© d'une substance supГ©rieure Г l'apport humain normal est ingГ©rГ©e. L'adГ©nosine est un neurotransmetteur qui se lie normalement aux rГ©cepteurs cellulaires du cerveau et qui rend les cellules plus actives et libГЁre de la dopamine. On a dГ©couvert qu'il avait des propriГ©tГ©s antioxydantes et qu'il augmentait les niveaux de sГ©rotonine et de dopamine dans le cerveau. La dose recommandГ©e varie, mais lorsqu'une personne utilise le mГ©dicament pour la premiГЁre fois, elle peut ГЄtre prise sans tenir compte du moment de la dose de la veille, alors que des doses plus importantes sont souvent prises aprГЁs le dГ®ner ou lorsque le corps est le plus endormi. Ne conduisez pas ou n'utilisez pas de machinerie lourde si vous prenez Modafinil. Le modafinil agit Г©galement sur les rГ©cepteurs de la noradrГ©naline et de la dopamine dans le cerveau. Quelques saisies ont Г©tГ© signalГ©es. Nootropique En France En inhibant Г la fois les transporteurs de la dopamine et de la sГ©rotonine, le modafinil empГЄche la rГ©absorption de la sГ©rotonine. C'est un mГ©lange racГ©mique de deux Г©nantiomГЁres, la dextro- et la lГ©vodropropyl amphГ©tamine. Les chats qui ont Г©tГ© traitГ©s avec du modafinil s'endorment souvent soudainement et tombent du lit. Un WEEA est un agent pharmacologique qui amГ©liore l'Г©veil de maniГЁre rapide. La dose commence habituellement Г 100 mg et peut ГЄtre augmentГ©e jusqu'Г 400 mg Г 800 mg. Le modafinil est Г©galement dГ©conseillГ© aux personnes souffrant d'une maladie grave des reins ou du foie, ou d'arythmie. Ne pas utiliser pendant la grossesse ou Г tout moment si vous allaitez. Le nom commercial approuvГ© aux Г‰tats-Unis est Provigil. Le mГ©dicament doit ГЄtre pris avec les repas pour diminuer le risque de nausГ©es. De plus, les rapports d'effets nГ©gatifs aprГЁs de fortes doses d'Г©phГ©dra ne sont pas signalГ©s avec le modafinil. Le modafinil a Г©tГ© classГ© aux Г‰tats-Unis comme une substance de l'annexe IV, bien qu'il puisse avoir Г©tГ© mal classГ©, car il fait l'objet de diverses demandes de brevet dans diverses juridictions. Les neurotransmetteurs cГ©rГ©braux sont responsables de ce que nous ressentons. Certains effets secondaires graves peuvent inclure des rГ©actions allergiques telles que l'anaphylaxie, les hallucinations et le lupus.
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