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C'est un agent neuroprotecteur, censé inhiber la formation d'oxyde nitrique (NO) et de ses métabolites dans le cerveau des souris. En 2014, il a été révélé que les National Institutes of Health avaient examiné une étude de 2012 suggérant que le modafinil pouvait améliorer la concentration et la mémoire chez les jeunes adultes en bonne santé. Le médicament est commercialisé sous forme de sel de chlorhydrate. Les adultes reçoivent généralement 200 mg. Le modafinil est indiqué pour les troubles du sommeil. Le modafinil n'est pas métabolisé par le CYP1A2, le CYP2D6, le CYP2E1, le CYP2C8 ou le CYP2C9. Au Royaume-Uni, le modafinil est un médicament d'ordonnance classé comme substance de l'annexe IV. D'autres effets secondaires peuvent inclure des troubles du sommeil, des problèmes de concentration et des nausées. La dose thérapeutique de modafinil pour le traitement des troubles du sommeil est de 100 à 200 mg pris environ une à deux heures avant le coucher. Cela agit principalement en stimulant la partie "noradrénergique" du cortex cérébral, bien qu'il soit également associé à l'augmentation de la libération de noradrénaline. Il est chimiquement classé comme un dérivé imidazo-azapyridine. Stimulant Intellectuel Sans Ordonnance Les patients ont ressenti une excitation du sommeil et ont cessé de dormir, alors le Dr Caro et le Dr Lewy ont ajouté un groupe isobutyle à la molécule et ont créé le médicament connu sous le nom de Modafinil. Il n'y a aucune preuve de modifications posologiques en fonction de l'âge, du sexe ou de la taille corporelle. Le modafinil semble affecter le cycle de sommeil du cerveau, augmentant l'éveil et l'attention. Il est commercialisé sous les noms de marque Provigil (Finzel) en Australie, au Canada, au Royaume-Uni, en France et en Afrique du Sud, et sous forme injectable en Italie. L'effet secondaire le plus courant du modafinil est un mal de tête. Les effets secondaires graves peuvent inclure des réactions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antécédents de psychose. Le modafinil est un médicament stimulant utilisé pour traiter la somnolence due à la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. Le médicament peut également être utilisé pour les troubles du sommeil liés au travail posté, une condition dans laquelle les personnes présentent des symptômes de narcolepsie mais sont obligées de travailler normalement pendant leurs heures de sommeil. Le modafinil peut être pris de 1 à 4 fois par jour. Ces méthodes sont généralement utilisées pour produire le médicament à des fins de recherche uniquement. Il peut également produire une légère euphorie et un besoin diminué de dormir. Il diffère du composé précédent, l'armodafinil (2-[(2R,3S)-2,3-dihydroxy-2-(méthylthio)éthyl]-5-méthyl-1-[(1H-tétrazol-5-yl)méthyl] -1H-tétrazole-4-acide carboxylique (2S)-2,3,4-trihydroxy-6-méthyl-3,7-dioxabicyclo[3. Le médicament contient 200 mg de modafinil et la posologie recommandée est de 200 à 400 mg chaque matin. La plupart des recherches sur le modafinil ne tiennent pas compte des interactions avec les aliments, l'alcool ou les médicaments qui altèrent la fonction cérébrale. Le manque de données de sécurité peut affecter les décisions de prescription.

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Il peut Г©galement ГЄtre administrГ© par voie intraveineuse, intranasale, sublinguale et sous-cutanГ©e. Le modafinil pour une utilisation en vente libre est illГ©gal au Royaume-Uni et, comme il ne s'agit pas d'une substance contrГґlГ©e en vertu de la loi des Г‰tats-Unis, il n'est pas autrement limitГ©. Г‰vitez l'alcool pendant que vous prenez du modafinil. La FDA et d'autres rГ©gulateurs donnent leur approbation pour Provigil 75 mg une fois par jour, qui fournit 180 heures de sommeil s'il est pris comme indiquГ©, les fabricants notant que le dГ©but de l'action (bГ©nГ©fice thГ©rapeutique maximal) se produit gГ©nГ©ralement Г  environ 3 heures. L'utilisation Г  court et Г  long terme n'a montrГ© aucun effet nГ©faste sur la mГ©moire et l'apprentissage, mais l'utilisation Г  long terme chez le rat a montrГ© une altГ©ration significative de la mГ©moire Г  long terme. Modafinil a une formule molГ©culaire de C14H13N et un poids molГ©culaire de 189,22 g/mol. Le modafinil est vendu en vente libre et sur ordonnance uniquement, en particulier pour le traitement de la somnolence. Le modafinil est utilisГ© pour traiter les personnes souffrant de narcolepsie sГ©vГЁre et de somnolence causГ©es par divers types de troubles du sommeil, notamment l'apnГ©e obstructive du sommeil, les troubles du sommeil liГ©s au travail postГ© et le dГ©calage horaire. Le modafinil peut augmenter la libГ©ration de dopamine, de noradrГ©naline et de sГ©rotonine dans le cerveau et est susceptible de s'opposer Г  la recapture de la dopamine et de la sГ©rotonine. Le modafinil est le plus couramment utilisГ© pour traiter la somnolence causГ©e par une somnolence excessive chez les personnes atteintes de narcolepsie, pour aider les troubles du sommeil liГ©s au travail postГ© et pour rГ©duire la somnolence chez les personnes souffrant d'apnГ©e obstructive du sommeil. En Europe, le modafinil est vendu par Bayer sous la marque Modalert. On pense que le modafinil exerce ses effets hypnotiques en augmentant la noradrГ©naline et la dopamine. Il doit ГЄtre utilisГ© avec prudence chez les personnes souffrant de problГЁmes rГ©naux ou hГ©patiques. Il est utilisГ© pour traiter la narcolepsie et d'autres troubles qui provoquent une somnolence excessive. Cependant, le modafinil n'est pas considГ©rГ© comme une dГ©pendance, bien que les gens puissent ressentir certains effets secondaires, notamment l'insomnie et les maux de tГЄte. Stimulant Intellectuel Sans Ordonnance Les doses courantes dans les essais cliniques vont de 200 mg Г  400 mg. Il est vendu sous forme de comprimГ© de 100 mg, 200 mg, 300 mg ou 400 mg. Le modafinil peut ГЄtre utilisГ© pour augmenter la durГ©e d'Г©veil chez les travailleurs postГ©s. Il n'a pas Г©tГ© dГ©montrГ© que le modafinil amГ©liore la mГ©moire ou l'apprentissage, bien qu'il puisse avoir des avantages psychologiques aigus. Des doses de modafinil de 50 mg Г  200 mg prises une fois par jour, le matin ou le soir, constituent la dose la plus courante. La plupart des formulations disponibles uniquement sur ordonnance sont disponibles sous forme de pilules, de comprimГ©s ou de gГ©lules. Il est Г©galement librement soluble dans le chloroforme et l'Г©ther de pГ©trole et partiellement soluble dans l'isopropanol. Il ne doit pas ГЄtre pris plus de 4 fois par jour. L'ingrГ©dient actif du modafinil est appelГ© D-100. Le modafinil est un mГ©dicament sympathomimГ©tique. Il amГ©liore la norГ©pinГ©phrine en inhibant l'enzyme monoamine oxydase (MAO-A), empГЄchant ainsi la dГ©gradation de ce neurotransmetteur. Le mГ©canisme d'action exact du modafinil n'est pas clair. Le modafinil affecte le SNC en agissant sur des sites du cerveau qui contrГґlent l'Г©veil et le sommeil. Selon la dose, il peut avoir un effet toxique sur le foie chez le rat. Il n'est pas recommandГ© aux personnes souffrant d'hypertension non contrГґlГ©e d'utiliser le modafinil.

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