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La prise de modafinil n'empГЄche pas la nГ©cessitГ© d'un horaire de sommeil rГ©gulier. Le modafinil fait partie d'une classe de mГ©dicaments appelГ©s modulateurs de l'Г©veil, qui agissent tous sur le SNC. Le modafinil est gГ©nГ©ralement sГ»r et bien tolГ©rГ©. Le modafinil est plus puissant que le desmГ©thyl-modafinil. Dans une Г©tude rГ©cente, le mГ©dicament a amГ©liorГ© les mesures de l'Г©veil et des performances cognitives chez les adultes en bonne santГ©, avec une diminution de plus de 50 % du temps d'Г©veil et une amГ©lioration des performances cognitives. Modiodal Generique Il s'agit gГ©nГ©ralement d'un cristal microparticulaire (CDI) et se compose de deux formes cristallines distinctes : l'hГ©mihydrate de modafinil (C-H) et le dihydrate de modafinil (C-D). On ne sait pas si l'utilisation pendant la grossesse est sans danger. Il est principalement commercialisГ© aux Г‰tats-Unis sous le nom de marque Provigil. Une Г©tude suggГЁre que le modafinil augmente les niveaux de sГ©rotonine, mais cela reste Г confirmer. De plus, il semble augmenter l'inhibition des neurones dopaminergiques induisant le sommeil dans l'hypothalamus. Il a Г©tГ© spГ©culГ© que Modafinil augmente les niveaux de sГ©rotonine dans l'hypothalamus et diminue sa libГ©ration dans le thalamus, amГ©liorant la libГ©ration de GABA au niveau de la synapse thalamo-corticale. Il peut agir sur le transporteur de noradrГ©naline et avoir un impact sur les systГЁmes dopaminergique et glutamatergique. Le modafinil peut ГЄtre utilisГ© en association avec divers mГ©dicaments ; cependant, il y a quelques prГ©cautions Г prendre. La prise de modafinil peut augmenter la probabilitГ© d'effets secondaires cognitifs, tels que des maux de tГЄte et des troubles du sommeil. En 2002, il a Г©tГ© recommandГ© pour le traitement des troubles du sommeil liГ©s au travail postГ©. AprГЁs cette pГ©riode, les effets ont Г©tГ© mesurГ©s et il a Г©tГ© constatГ© que le groupe de 400 mg montrait une amГ©lioration significative de sa vigilance globale et de sa capacitГ© Г rГ©agir pendant les heures de veille, mesurГ©e par un test de flexibilitГ© cognitive. Contrairement Г la plupart des autres stimulants du SNC, il agit via un mГ©canisme d'action diffГ©rent de celui des amphГ©tamines. Aux Г‰tats-Unis, les comprimГ©s se distinguent par une Г©tiquette mettant en garde contre les effets secondaires du modafinil, ainsi qu'une liste des conditions mГ©dicales pour lesquelles le mГ©dicament n'est pas indiquГ©, car cela peut indiquer une mauvaise utilisation intentionnelle du produit. Dans les essais cliniques, les sujets prenant Modafinil ont signalГ© une augmentation de l'attention, des niveaux d'Г©nergie et de la vigilance sans effets secondaires significatifs. La dose maximale moyenne pour une utilisation Г long terme est d'environ 430 mg/jour chez l'adulte et de 320 mg/jour chez l'enfant.
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Le modafinil a Г©tГ© dГ©veloppГ© Г l'origine pour ГЄtre utilisГ© dans la recherche sur le sommeil et a Г©tГ© utilisГ© pour traiter la narcolepsie et d'autres troubles du sommeil pendant des dГ©cennies avant d'entrer sur le marchГ© en tant que mГ©dicament d'ordonnance en 1997. Plus de 50 % du reste est excrГ©tГ© dans la bile. Le modafinil peut abaisser la tension artГ©rielle et doit ГЄtre utilisГ© avec prudence chez les patients souffrant d'hypertension. Cela Г©quivaut Г environ 75 Г 100 mg d'ingrГ©dient actif. Le modafinil agit Г©galement comme un antagoniste non sГ©lectif de l'histamine H1 et H2 rГ©cepteurs. Il est disponible pour un dosage par intervalles de 30 minutes ou d'1 heure. Les plus courants d'entre eux comprennent les maux de tГЄte, les troubles du sommeil, les effets gastro-intestinaux et les nausГ©es. Modiodal Generique Ils mesurent environ 5 mm de diamГЁtre et contiennent une dose de 100 mg de l'ingrГ©dient actif. Il est gГ©nГ©ralement pris quelques heures avant le coucher. La stimulation de la dopamine dans cette zone du cerveau rГ©gule Г©galement les rГ©ponses Г©motionnelles telles que les sentiments d'anxiГ©tГ©, de tristesse et de dГ©pression. Comme d'autres mГ©dicaments stimulants, le modafinil augmente les niveaux de dopamine (l'un des produits chimiques prГ©sents dans le cerveau qui envoie des messages chimiques au reste du corps) et de noradrГ©naline (un autre produit chimique dans le cerveau, qui, entre autres, ralentit le corps). Cependant, une taille plus petite a Г©tГ© annoncГ©e en l'an 2000. Une augmentation supplГ©mentaire de la dose Г 200 mg peut ГЄtre nГ©cessaire chez les personnes qui ne prГ©sentent pas une diminution suffisante de la somnolence. Cependant, son efficacitГ© pour le traitement des troubles du sommeil liГ©s au travail postГ© et de l'apnГ©e obstructive du sommeil n'a pas Г©tГ© Г©tablie. Le citrate de modafinil (acide libre de modafinil) est un sel de l'ingrГ©dient actif modafinil, qui n'est pas une substance contrГґlГ©e aux Г‰tats-Unis, mais est contrГґlГ© par la lГ©gislation de l'Union europГ©enne et du Canada. La prГ©paration de modafinil peut activer les voies du SNC liГ©es Г l'Г©veil et amГ©liorer le niveau global d'Г©veil. Le mГ©dicament agit comme un agoniste pour un type de rГ©cepteur de la dopamine, le rГ©cepteur D4. Pile d'amГ©lioration cognitive En raison de la similitude chimique du modafinil et du mГ©thylphГ©nidate, de nombreuses personnes utilisent les deux mГ©dicaments en tandem. Les rГ©sultats positifs qui ont Г©tГ© observГ©s dans la vie de nombreuses personnes ont conduit Г la rГ©alisation de nombreuses Г©tudes pour comprendre les mГ©canismes sous-jacents du fonctionnement du modafinil et oГ№ les effets souhaitГ©s et les effets indГ©sirables se produisent dans le cerveau. Il a Г©tГ© initialement dГ©veloppГ© en tant que composГ© nootropique et Г©tait Г l'origine connu sous le nom de code N617. Modafinil est fabriquГ© par Cephalon. Certaines personnes qui prennent Modafinil ont signalГ© une aggravation des symptГґmes de la narcolepsie ou des troubles du sommeil.
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