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Semblable à l'amphétamine, la drogue est un isomère au centre chiral, et les isomères R et L ont des propriétés pharmacologiques différentes, bien que les deux sels agissent de manière similaire. Le modafinil est classé comme médicament stimulant. Le médicament doit être pris avant le coucher car il n'y a pas d'effet précoce. L'effet net est d'augmenter le niveau de vigilance, ce qui peut entraîner une augmentation de l'état de veille. Il a été rapporté que le modafinil traverse la barrière hémato-encéphalique, bien que son emplacement et son effet exacts n'aient pas été confirmés. Modalert Canada Il a également été étudié et jugé utile dans le traitement des troubles du sommeil liés au travail posté. Pour le traitement de l'apnée obstructive du sommeil, la dose recommandée est de 100 à 300 mg trois fois par jour. Le modafinil est un inhibiteur très puissant de la monoamine oxydase (MAO). Le modafinil peut également augmenter ou diminuer la tension artérielle. Il est également déconseillé aux personnes atteintes d'hyperplasie de la prostate. Il est considéré comme un substitut possible du Ritalin et d'autres médicaments stimulants. Les participants à l'étude ayant des antécédents de trouble du travail posté ont été divisés en groupes et ont reçu un placebo ou du modafinil dans deux études distinctes. Le modafinil est vendu aux États-Unis sous forme de médicament à libération prolongée (R -modafinil a été mis à disposition en 2007 par Sun Pharmaceuticals) comprimé, un comprimé à libération prolongée de marque (Modvigil), par Modafinil Citrus, et en tant que médicament générique. Le modafinil est généralement bien toléré, avec des effets secondaires possibles, notamment des maux de tête, des troubles du sommeil et des nausées. Le modafinil est un antagoniste alpha-1, ce qui signifie qu'il bloque les récepteurs noradrénergiques alpha-1 dans le cerveau. Il est généralement pris avec ou sans nourriture. Le modafinil a été qualifié d'"agoniste de la dopamine", car il semble être un agoniste dans le cortex préfrontal et l'hypothalamus, et plutôt un antagoniste ailleurs dans le cerveau. Si le risque de préjudice grave est élevé, Modafinil doit être arrêté.

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En raison de problГЁmes de prise de poids et des dangers d'une consommation excessive de cafГ©ine ou d'amphГ©tamines, l'utilisation du modafinil est toujours limitГ©e par la FDA au traitement de la narcolepsie, et il n'a Г©tГ© approuvГ© pour cette utilisation qu'aux Г‰tats-Unis. Le modafinil n'est pas approuvГ© par la Food and Drug Administration (FDA) pour une utilisation comme activateur cognitif aux Г‰tats-Unis, mais il a Г©tГ© utilisГ© aux Г‰tats-Unis hors AMM. Dans la narcolepsie, le modafinil peut gГ©nГ©ralement ГЄtre pris sans danger avec ou sans nourriture, bien qu'il puisse parfois provoquer de lГ©gers effets secondaires gastro-intestinaux, tels que nausГ©es, vomissements et constipation. Le modafinil n'affecte pas la fonction du cЕ“ur ou des vaisseaux sanguins, ce qui le rend sans danger pour les patients atteints de maladies cardiovasculaires. Le modafinil a Г©galement Г©tГ© utilisГ© pour augmenter la tolГ©rance Г  la cafГ©ine et rГ©veiller les individus Г  tolГ©rance limitГ©e. Acheter Modafinil Sans Ordonnance Chaque pilule contient 10 mg de mГ©dicament. Les autres effets secondaires comprennent les nausГ©es, les maux de tГЄte, les douleurs abdominales, la diarrhГ©e et le prurit. En dehors de la somnolence, les avantages potentiels du modafinil pour amГ©liorer d'autres aspects de la fonction cognitive n'ont pas Г©tГ© Г©tablis. Des doses plus importantes de modafinil peuvent ГЄtre utilisГ©es si nГ©cessaire. Le modafinil peut provoquer des effets secondaires dont la gravitГ© varie de lГ©gГЁre Г  potentiellement mortelle. Les mГ©decins peuvent le prescrire aux personnes atteintes de narcolepsie alors qu'elles essaient d'ajuster leur cycle veille-sommeil, ou aux personnes qui ont dГ©veloppГ© par inadvertance un cycle de sommeil circadien dГ©calГ© ou Г  l'opposГ© de ce que devrait ГЄtre le cycle circadien naturel de la personne. Pour les adultes prГ©sentant un risque de psychose, le modafinil doit ГЄtre utilisГ© avec une extrГЄme prudence et uniquement sous surveillance mГ©dicale Г©troite. Il est Г©galement utilisГ© pour les symptГґmes d'une hygiГЁne de sommeil inadГ©quate sur le lieu de travail, en particulier la difficultГ© Г  s'endormir, le rГ©veil tГґt le matin et la sensation de fatigue au rГ©veil. Le modafinil est un substrat du transporteur de cations organiques 2 (OCT2). Le modafinil a Г©tГ© isolГ© Г  partir des graines de plantes originaires du BrГ©sil et a Г©tГ© brevetГ© en 1989. On dit qu'elle a un mГ©canisme d'action similaire Г  la cocaГЇne, mais avec moins de risque de potentiel addictif.

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