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Il peut Г©galement augmenter l'excitation corticale en stimulant les neurones thalamiques. Dans le passГ©, le modafinil de qualitГ© commerciale Г©tait Г©galement vendu sous les noms de Cerefol, Rendat et Avinza, entre autres. Le mГ©canisme d'action exact et les effets secondaires possibles du modafinil ne sont pas entiГЁrement compris et une enquГЄte plus approfondie est nГ©cessaire pour prouver que le modafinil est responsable de l'augmentation signalГ©e de l'Г©veil. On pense qu'il agit en stimulant plusieurs rГ©cepteurs dans le cerveau. Les effets peuvent varier selon les zones du cerveau touchГ©es et l'heure de la journГ©e Г laquelle le mГ©dicament est pris. Il s'agit d'un somnifГЁre sur ordonnance utilisГ© principalement pour traiter la narcolepsie. Modiodal Generique Il existe Г©galement plusieurs types diffГ©rents de ce mГ©dicament, notamment le citrate de modafinil et le modafinil sans saveur. Si vous souhaitez l'utiliser Г vos propres fins, vous le pouvez. Le modafinil amГ©liore Г©galement la rГ©ponse du SNC Г la dopamine, ce qui peut contribuer Г l'augmentation de l'Г©veil et de l'Г©veil. Lorsqu'il est pris rГ©guliГЁrement pendant plusieurs jours, le mГ©dicament augmente l'Г©veil de maniГЁre dose-dГ©pendante. Cela peut Г©galement amГ©liorer la mГ©moire de travail. Si cela se produit pendant que vous prenez du modafinil, parlez-en immГ©diatement Г votre mГ©decin. Le modafinil agit en modulant la liaison du modafinil au transporteur de la sГ©rotonine (5-HTT). Au moins aux Г‰tats-Unis, le modafinil est considГ©rГ© comme une utilisation hors AMM pour l'amГ©lioration de la cognition, mais la recherche a montrГ© que le modafinil Г©tait utile Г cet Г©gard. Il agit Г©galement sur le rГ©cepteur de la sГ©rotonine 5-HT2A. Dans certaines Г©tudes animales, le modafinil s'est Г©galement avГ©rГ© amГ©liorer les capacitГ©s cognitives et amГ©liorer la motivation dans des conditions oГ№ la motivation et la rГ©compense Г©taient mesurГ©es (par ex. Modafinil XR est fourni par Aliva Pharmaceuticals, Inc. Le modafinil est prescrit en France depuis 1994 et a Г©tГ© approuvГ© pour un usage mГ©dical aux Г‰tats-Unis en 1998. C'est un dГ©rivГ© de la cafГ©ine chimique, et est un analogue de la cafГ©ine, agissant ainsi sur les rГ©cepteurs de l'adГ©nosine.
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Il est Г©galement parfois utilisГ© pour traiter l'apnГ©e obstructive du sommeil chez les personnes qui n'ont pas rГ©pondu aux autres traitements. Le modafinil ne s'est pas rГ©vГ©lГ© bГ©nГ©fique sur le plan clinique dans le traitement du trouble dГ©ficitaire de l'attention avec hyperactivitГ© chez les enfants et les adultes. Plus de 40 % des personnes qui en prennent ne signalent aucun effet secondaire notable, tandis que 14 % signalent des effets secondaires tels que des maux de tГЄte, des troubles du sommeil et des nausГ©es. Au Royaume-Uni, le modafinil est un mГ©dicament d'ordonnance classГ© comme substance de l'annexe IV. Le modafinil est Г©galement une substance contrГґlГ©e. Son profil pharmacodynamique est diffГ©rent de celui du sulfate de modafinil : comme le modafinil lui-mГЄme, le mГ©tabolite du modafinil est mГ©tabolisГ© par l'enzyme CYP1A2, alors que le sulfate de modafinil ne l'est pas. Provigil, Г©galement appelГ© modafinil, est un mГ©dicament favorisant l'Г©veil. Modalert Canada Il peut ГЄtre pris avec ou sans nourriture. Le modafinil est utilisГ© pour traiter le trouble du sommeil liГ© au travail postГ©, dans lequel une personne qui est Г©veillГ©e la nuit dГ©cale ses heures de veille. Il se prГ©sente sous la forme d'une poudre cristalline blanche Г blanc cassГ©, qui peut ГЄtre transformГ©e en une solution limpide et inodore pour injection ou pour pulvГ©risation nasale. Il est le plus souvent utilisГ© pour augmenter l'Г©veil. Il culmine en deux Г trois heures et prend entre six et huit heures pour se dissiper. Si la phase de sommeil dure plus de 3 heures, la dose est de 200 mg. Le modafinil est vendu pour traiter divers troubles du sommeil, la majoritГ© des Г©tudes portant sur les conditions des travailleurs postГ©s, l'apnГ©e obstructive du sommeil et la narcolepsie. f. Comme d'autres mГ©dicaments apparentГ©s, Modafinil est un stimulant du systГЁme nerveux central. La posologie recommandГ©e est de 200 Г 400 mg avant le coucher. Dans deux Г©tudes de population en 2007, des crises se sont produites chez moins de 1% des personnes qui ont pris du Modafinil. Le modafinil fonctionne Г©galement comme inhibiteur du transporteur de la phГ©nylГ©thylamine et comme antagoniste des rГ©cepteurs de la sГ©rotonine. La posologie recommandГ©e est de 100 Г 200 mg pris environ 4 Г 9 heures avant le coucher.
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